Heat Shock Proteins As Biomarkers of Lung Cancer

Overview

Journal Cancer Biol Ther

Specialties Oncology
Pharmacology

Date 2020 Apr 2

PMID 32228356

Citations 24

Authors

Sonam Mittal

Maitreyi S Rajala

Affiliations

Soon will be listed here.

Abstract

Heat shock proteins are known to be associated with a wide variety of human cancers including lung cancer. Overexpression of these molecular chaperones is linked with tumor survival, metastasis and anticancer drug resistance. In recent years, heat shock proteins are gaining much importance in the field of cancer research owing to their potential to be key determinants of cell survival and apoptosis. Lung cancer is one of the most common cancers diagnosed worldwide and the association of heat shock proteins in lung cancer diagnosis, prognosis and as drug targets remains unresolved. The aim of this review is to draw the importance of heat shock protein members; Hsp27, Hsp70, Hsp90, Hsp60 and their diagnostic and prognostic implications in lung cancer. Based on the available literature heat shock proteins can serve as biomarkers and anticancer drug targets in the management of lung cancer patients.

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References

Hsu H, Lin J, Huang W, Hsu T, Su K, Chiou S . Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27. Cancer. 2011; 117(7):1516-28. DOI: 10.1002/cncr.25599. View

Wu C . Heat shock transcription factors: structure and regulation. Annu Rev Cell Dev Biol. 1995; 11:441-69. DOI: 10.1146/annurev.cb.11.110195.002301. View

Calderwood S, Gong J . Heat Shock Proteins Promote Cancer: It's a Protection Racket. Trends Biochem Sci. 2016; 41(4):311-323. PMC: 4911230. DOI: 10.1016/j.tibs.2016.01.003. View

Whitesell L, Lindquist S . HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005; 5(10):761-72. DOI: 10.1038/nrc1716. View

Havasi A, Li Z, Wang Z, Martin J, Botla V, Ruchalski K . Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2008; 283(18):12305-13. PMC: 2431006. DOI: 10.1074/jbc.M801291200. View

Endo H, Yano M, Okumura Y, Kido H . Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70. Cell Death Dis. 2014; 5:e1027. PMC: 4040650. DOI: 10.1038/cddis.2013.550. View

Huang Z, Li H, Sun Z, Zheng J, Zhao R, Chen J . Distinct prognostic roles of HSPB1 expression in non-small cell lung cancer. Neoplasma. 2017; 65(1):161-166. DOI: 10.4149/neo_2018_102. View

Calderwood S, Khaleque M, Sawyer D, Ciocca D . Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. 2006; 31(3):164-72. DOI: 10.1016/j.tibs.2006.01.006. View

Multhoff G, Mizzen L, Winchester C, Milner C, Wenk S, Eissner G . Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol. 1999; 27(11):1627-36. DOI: 10.1016/s0301-472x(99)00104-6. View

10.

Xu T, Wei Q, Lopez Guerra J, Wang L, Liu Z, Gomez D . HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2012; 84(2):e229-35. PMC: 3426644. DOI: 10.1016/j.ijrobp.2012.03.032. View

11.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

12.

Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F . Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival. J Clin Oncol. 2010; 28(11):1928-35. DOI: 10.1200/JCO.2009.24.4954. View

13.

Powers M, Clarke P, Workman P . Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell. 2008; 14(3):250-62. DOI: 10.1016/j.ccr.2008.08.002. View

14.

Weng D, Song B, Durfee J, Sugiyama V, Wu Z, Koido S . Induction of cytotoxic T lymphocytes against ovarian cancer-initiating cells. Int J Cancer. 2010; 129(8):1990-2001. DOI: 10.1002/ijc.25851. View

15.

Netzer W, Hartl F . Protein folding in the cytosol: chaperonin-dependent and -independent mechanisms. Trends Biochem Sci. 1998; 23(2):68-73. DOI: 10.1016/s0968-0004(97)01171-7. View

16.

Malusecka E, Zborek A, Krzyzowska-Gruca S, Krawczyk Z . Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study. Anticancer Res. 2001; 21(2A):1015-21. View

17.

Xu W, Soga S, Beebe K, Lee M, Kim Y, Trepel J . Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition. Br J Cancer. 2007; 97(6):741-4. PMC: 2360392. DOI: 10.1038/sj.bjc.6603950. View

18.

Li S, Zhang W, Fan J, Lai Y, Che G . Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis. Springerplus. 2016; 5(1):1165. PMC: 4960090. DOI: 10.1186/s40064-016-2827-8. View

19.

Shevtsov M, Nikolaev B, Yakovleva L, Parr M, Marchenko Y, Eliseev I . 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma. J Control Release. 2015; 220(Pt A):329-340. DOI: 10.1016/j.jconrel.2015.10.051. View

20.

Berrieman H, Cawkwell L, OKane S, Smith L, Lind M . Hsp27 may allow prediction of the response to single-agent vinorelbine chemotherapy in non-small cell lung cancer. Oncol Rep. 2005; 15(1):283-6. View