Epigenetic Metabolites License Stem Cell States

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2020 Mar 30

PMID 32220298

Citations 8

Authors

Logeshwaran Somasundaram

Shiri Levy

Abdiasis M Hussein

Devon D Ehnes

Julie Mathieu

Hannele Ruohola-Baker

Affiliations

Soon will be listed here.

Abstract

It has become clear during recent years that stem cells undergo metabolic remodeling during their activation process. While these metabolic switches take place in pluripotency as well as adult stem cell populations, the rules that govern the switch are not clear. In this review, we summarize some of the transitions in adult and pluripotent cell types and will propose that the key function in this process is the generation of epigenetic metabolites that govern critical epigenetic modifications, and therefore stem cell states.

Citing Articles

Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation.

Yue F, Gu L, Qiu J, Oprescu S, Beckett L, Ellis J EMBO J. 2025; .

PMID: 40065099 DOI: 10.1038/s44318-025-00397-1.

Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential.

Liu Y, Wang L, Ai J, Li K Stem Cell Rev Rep. 2024; 20(3):617-636.

PMID: 38265576 DOI: 10.1007/s12015-024-10681-y.

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis.

Li Q, Wang O, Ji B, Zhao L, Zhao L Nutrients. 2023; 15(13).

PMID: 37447280 PMC: 10346806. DOI: 10.3390/nu15132953.

Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs.

Taslim T, Hussein A, Keshri R, Ishibashi J, Chan T, Nguyen B Stem Cell Reports. 2022; 18(1):269-288.

PMID: 36493777 PMC: 9860083. DOI: 10.1016/j.stemcr.2022.11.004.

An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity.

Li D, Yang J, Malik V, Huang Y, Huang X, Zhou H Nucleic Acids Res. 2022; 50(21):12462-12479.

PMID: 36416264 PMC: 9757061. DOI: 10.1093/nar/gkac1084.