The Bologna Motor and Non-motor Prospective Study on Parkinsonism at Onset (BoProPark): Study Design and Population

Overview

Journal Neurol Sci

Specialty Neurology

Date 2020 Mar 29

PMID 32219591

Citations 5

Authors

Giovanna Calandra-Buonaura

Luisa Sambati

Francesca Baschieri

Maria Vitiello

Manuela Contin

Caterina Tonon

Sabina Capellari

Federica Provini

Pietro Cortelli

Affiliations

Soon will be listed here.

Abstract

Objective: The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark) was designed to prospectively characterize motor and non-motor features in patients with a progressive neurodegenerative disease starting with parkinsonism since early disease stage and to investigate their diagnostic and prognostic role in the differential diagnosis of Parkinson's disease from atypical parkinsonisms. The aim of this paper is to describe the method and population of the BoProPark study.

Methods: Patients referred to our Department with parkinsonism within 3 years from motor onset were recruited. Secondary causes of parkinsonism were excluded. Each patient underwent a comprehensive evaluation of motor and non-motor symptoms, assessed by means of quantitative, objective instrumental tests in addition to scales and questionnaires. The evaluations were performed at enrolment (T0), after 16 months (T1) and after 5 years (T2). Diagnoses were made according to consensus criteria.

Results: We recruited 150 patients, with mean age 61.5 ± 9.8 years and mean disease duration 20 ± 9 months. H&Y stage was 1 in 47.3% and 2 in 46.7% of cases. Mean UPDRS-III was 17.7 ± 9.2. Fifty-four patients were on dopaminergic treatment with median levodopa equivalent daily dose (LEDD) of 200 mg.

Conclusions: We expect that the prospective nature of the BoProPark study as well as the comprehensive, instrumental evaluation of motor and non-motor symptoms in patients with parkinsonism will provide important new insights for both clinical practice and research. Our data could be used for comparison with other cohorts and shared with national and international collaborators to develop new innovative projects.

Citing Articles

Comment to the article titled: sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson's disease.

Cani I, Guaraldi P, Sambati L, Cortelli P, Calandra-Buonaura G Clin Auton Res. 2024; 34(6):607-608.

PMID: 39133344 DOI: 10.1007/s10286-024-01057-w.

The Degree of Cardiovascular Autonomic Dysfunction is not Different in GBA-Related and Idiopathic Parkinson's Disease Patients: A Case-Control Instrumental Evaluation.

Giannini G, Minardi R, Barletta G, Cani I, Cecere A, Baldelli L J Parkinsons Dis. 2024; 14(2):335-346.

PMID: 38306061 PMC: 10977396. DOI: 10.3233/JPD-230334.

Levodopa-induced orthostatic hypotension in parkinsonism: A red flag of autonomic failure.

Cani I, Guaraldi P, Giannini G, Sambati L, Barletta G, Cortelli P Eur J Neurol. 2023; 31(1):e16061.

PMID: 37724992 PMC: 11235727. DOI: 10.1111/ene.16061.

Neurofilament light chain and α-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes.

Quadalti C, Calandra-Buonaura G, Baiardi S, Mastrangelo A, Rossi M, Zenesini C NPJ Parkinsons Dis. 2021; 7(1):93.

PMID: 34635674 PMC: 8505434. DOI: 10.1038/s41531-021-00232-4.

Quantitative Assessment of Motor Response to a Low Subacute Levodopa Dose in the Differential Diagnosis of Parkinsonisms at Disease Onset: Data from the BoProPark Cohort.

Contin M, Lopane G, Cortelli P, Sambati L, Mohamed S, Calandra-Buonaura G J Parkinsons Dis. 2021; 11(2):811-819.

PMID: 33554924 PMC: 8150440. DOI: 10.3233/JPD-202262.

References

Ali K, Morris H . Parkinson's disease: chameleons and mimics. Pract Neurol. 2014; 15(1):14-25. DOI: 10.1136/practneurol-2014-000849. View

Elkouzi A, Vedam-Mai V, Eisinger R, Okun M . Emerging therapies in Parkinson disease - repurposed drugs and new approaches. Nat Rev Neurol. 2019; 15(4):204-223. PMC: 7758837. DOI: 10.1038/s41582-019-0155-7. View

Boxer A, Yu J, Golbe L, Litvan I, Lang A, Hoglinger G . Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. Lancet Neurol. 2017; 16(7):552-563. PMC: 5802400. DOI: 10.1016/S1474-4422(17)30157-6. View

Hughes A, Daniel S, Ben-Shlomo Y, Lees A . The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain. 2002; 125(Pt 4):861-70. DOI: 10.1093/brain/awf080. View

Contin M, Riva R, Martinelli P, Albani F, Avoni P, Baruzzi A . Levodopa therapy monitoring in patients with Parkinson disease: a kinetic-dynamic approach. Ther Drug Monit. 2002; 23(6):621-9. DOI: 10.1097/00007691-200112000-00005. View

Ewing D . Cardiovascular reflexes and autonomic neuropathy. Clin Sci Mol Med. 1978; 55(4):321-7. DOI: 10.1042/cs0550321. View

Visser M, Marinus J, Stiggelbout A, van Hilten J . Assessment of autonomic dysfunction in Parkinson's disease: the SCOPA-AUT. Mov Disord. 2004; 19(11):1306-12. DOI: 10.1002/mds.20153. View

Vetrugno R, Provini F, Cortelli P, Plazzi G, Lotti E, Pierangeli G . Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study. Sleep Med. 2004; 5(1):21-30. DOI: 10.1016/j.sleep.2003.07.002. View

Chaudhuri K, Pal S, DiMarco A, Whately-Smith C, Bridgman K, Mathew R . The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2002; 73(6):629-35. PMC: 1757333. DOI: 10.1136/jnnp.73.6.629. View

10.

Scaglione C, Vignatelli L, Plazzi G, Marchese R, Negrotti A, Rizzo G . REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study. Neurol Sci. 2005; 25(6):316-21. DOI: 10.1007/s10072-004-0364-7. View

11.

Walters A . Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord. 1995; 10(5):634-42. DOI: 10.1002/mds.870100517. View

12.

Walters A, LeBrocq C, Dhar A, Hening W, Rosen R, Allen R . Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003; 4(2):121-32. DOI: 10.1016/s1389-9457(02)00258-7. View

13.

Vignatelli L, Plazzi G, Barbato A, Ferini-Strambi L, Manni R, Pompei F . Italian version of the Epworth sleepiness scale: external validity. Neurol Sci. 2003; 23(6):295-300. DOI: 10.1007/s100720300004. View

14.

Peto V, Jenkinson C, Fitzpatrick R . PDQ-39: a review of the development, validation and application of a Parkinson's disease quality of life questionnaire and its associated measures. J Neurol. 1998; 245 Suppl 1:S10-4. DOI: 10.1007/pl00007730. View

15.

Carlesimo G, Caltagirone C, Gainotti G . The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol. 1996; 36(6):378-84. DOI: 10.1159/000117297. View

16.

Beck A, Ward C, Mendelson M, Mock J, ERBAUGH J . An inventory for measuring depression. Arch Gen Psychiatry. 1961; 4:561-71. DOI: 10.1001/archpsyc.1961.01710120031004. View

17.

Adler C, Beach T, Hentz J, Shill H, Caviness J, Driver-Dunckley E . Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology. 2014; 83(5):406-12. PMC: 4132570. DOI: 10.1212/WNL.0000000000000641. View

18.

Hagell P, Widner H . Clinical rating of dyskinesias in Parkinson's disease: use and reliability of a new rating scale. Mov Disord. 1999; 14(3):448-55. DOI: 10.1002/1531-8257(199905)14:3<448::aid-mds1010>3.0.co;2-0. View

19.

Gallassi R, Sambati L, Maserati M, Poda R, Oppi F, De Matteis M . Simple verbal analogies test: normative data on a short task exploring abstract thinking. Aging Clin Exp Res. 2013; 26(1):67-71. DOI: 10.1007/s40520-013-0180-0. View

20.

Gallassi R, Lenzi P, Stracciari A, Lorusso S, Ciardulli C, Morreale A . Neuropsychological assessment of mental deterioration: purpose of a brief battery and a probabilistic definition of "normality" and "non-normality". Acta Psychiatr Scand. 1986; 74(1):62-7. DOI: 10.1111/j.1600-0447.1986.tb06228.x. View