Hepatic Artery Infusion Pumps

Overview

Journal J Surg Oncol

Specialties General Surgery
Oncology

Date 2020 Mar 28

PMID 32215927

Citations 10

Authors

Cornelius A Thiels

Michael I DAngelica

Affiliations

Soon will be listed here.

Abstract

The preferential blood supply from the hepatic artery to liver tumors allows for the regional delivery of chemotherapy, commonly referred to as hepatic artery infusion chemotherapy via a subcutaneous pump. Hepatic artery infusion chemotherapy has been demonstrated to improve overall survival in select patients with colorectal liver metastasis and is a promising treatment for unresectable intrahepatic cholangiocarcinoma. This review focuses on the technical aspects of hepatic artery infusion pump placement.

Citing Articles

Percutaneous transhepatic arterial access for coil embolization of hepatic artery infusion pump-associated bleeding.

Dutta A, Shankar V, Santos E, Marinelli B, Alexander E, Sotirchos V CVIR Endovasc. 2025; 8(1):5.

PMID: 39786466 PMC: 11717752. DOI: 10.1186/s42155-024-00515-w.

Bioinspired intratumoral infusion port catheter improves local drug delivery in the liver.

Pedersoli F, Mohammad I, Patel A, Kessler J, Chao C, Liu B Sci Rep. 2024; 14(1):27782.

PMID: 39538011 PMC: 11561066. DOI: 10.1038/s41598-024-79694-4.

Safety and efficacy of percutaneous arterial port Implantation for Hepatic Arterial Infusion Chemotherapy.

Meyblum L, Faron M, Deschamps F, Kobe A, Bonnet B, Boileve A Eur Radiol. 2024; 35(2):1022-1033.

PMID: 39080068 DOI: 10.1007/s00330-024-10887-1.

Hepatic arterial infusion chemotherapy with implantable arterial access port for advanced-stage hepatocellular carcinoma: a case report.

Jiang X, Aljbri A, Liu J, Shang L, Tian Y, Shao H Front Oncol. 2024; 14:1401882.

PMID: 38817896 PMC: 11137744. DOI: 10.3389/fonc.2024.1401882.

Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature.

Robinson T, Cummins K, Tsung A Curr Oncol. 2024; 31(2):1079-1090.

PMID: 38392074 PMC: 10887848. DOI: 10.3390/curroncol31020080.

References

ENSMINGER W, Gyves J . Clinical pharmacology of hepatic arterial chemotherapy. Semin Oncol. 1983; 10(2):176-82. View

Cercek A, Boerner T, Tan B, Chou J, Gonen M, Boucher T . Assessment of Hepatic Arterial Infusion of Floxuridine in Combination With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial. JAMA Oncol. 2019; 6(1):60-67. PMC: 6824231. DOI: 10.1001/jamaoncol.2019.3718. View

Qadan M, DAngelica M, Kemeny N, Cercek A, Kingham T . Robotic hepatic arterial infusion pump placement. HPB (Oxford). 2017; 19(5):429-435. PMC: 5633044. DOI: 10.1016/j.hpb.2016.12.015. View

WEISS L, Grundmann E, Torhorst J, Hartveit F, Moberg I, Eder M . Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol. 1986; 150(3):195-203. DOI: 10.1002/path.1711500308. View

Siegel R, Miller K, Jemal A . Cancer statistics, 2019. CA Cancer J Clin. 2019; 69(1):7-34. DOI: 10.3322/caac.21551. View

Konstantinidis I, Groot Koerkamp B, Do R, Gonen M, Fong Y, Allen P . Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone. Cancer. 2015; 122(5):758-65. PMC: 4764409. DOI: 10.1002/cncr.29824. View

Datta J, Narayan R, Kemeny N, DAngelica M . Role of Hepatic Artery Infusion Chemotherapy in Treatment of Initially Unresectable Colorectal Liver Metastases: A Review. JAMA Surg. 2019; 154(8):768-776. DOI: 10.1001/jamasurg.2019.1694. View

Cercek A, Boucher T, Gluskin J, Aguilo A, Chou J, Connell L . Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies. J Surg Oncol. 2016; 114(6):655-663. PMC: 5570459. DOI: 10.1002/jso.24399. View

Kemeny N, Huang Y, Cohen A, Shi W, Conti J, Brennan M . Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med. 1999; 341(27):2039-48. DOI: 10.1056/NEJM199912303412702. View

10.

Kemeny N, Niedzwiecki D, Hollis D, Lenz H, Warren R, Naughton M . Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481). J Clin Oncol. 2006; 24(9):1395-403. DOI: 10.1200/JCO.2005.03.8166. View

11.

Castaing D, Azoulay D, Fecteau A, Bismuth H . Implantable hepatic arterial infusion device: placement without laparotomy via an intercostal artery. J Am Coll Surg. 1998; 187(5):565-8. DOI: 10.1016/s1072-7515(98)00212-9. View

12.

Loupakis F, Cremolini C, Masi G, Lonardi S, Zagonel V, Salvatore L . Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med. 2014; 371(17):1609-18. DOI: 10.1056/NEJMoa1403108. View

13.

Valle J, Wasan H, Palmer D, Cunningham D, Anthoney A, Maraveyas A . Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010; 362(14):1273-81. DOI: 10.1056/NEJMoa0908721. View

14.

Kemeny N, Melendez F, Capanu M, Paty P, Fong Y, Schwartz L . Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma. J Clin Oncol. 2009; 27(21):3465-71. PMC: 3646304. DOI: 10.1200/JCO.2008.20.1301. View

15.

Hohn D, Rayner A, Economou J, Ignoffo R, Lewis B, Stagg R . Toxicities and complications of implanted pump hepatic arterial and intravenous floxuridine infusion. Cancer. 1986; 57(3):465-70. DOI: 10.1002/1097-0142(19860201)57:3<465::aid-cncr2820570311>3.0.co;2-s. View

16.

DAngelica M, Correa-Gallego C, Paty P, Cercek A, Gewirtz A, Chou J . Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes. Ann Surg. 2014; 261(2):353-60. PMC: 4578807. DOI: 10.1097/SLA.0000000000000614. View

17.

Breedis C, Young G . The blood supply of neoplasms in the liver. Am J Pathol. 1954; 30(5):969-77. PMC: 1942491. View

18.

Lorenz M, Muller H . Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from.... J Clin Oncol. 2000; 18(2):243-54. DOI: 10.1200/JCO.2000.18.2.243. View

19.

Nathan H, Aloia T, Vauthey J, Abdalla E, Zhu A, Schulick R . A proposed staging system for intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2008; 16(1):14-22. DOI: 10.1245/s10434-008-0180-z. View

20.

Allen P, Nissan A, Picon A, Kemeny N, Dudrick P, Ben-Porat L . Technical complications and durability of hepatic artery infusion pumps for unresectable colorectal liver metastases: an institutional experience of 544 consecutive cases. J Am Coll Surg. 2005; 201(1):57-65. DOI: 10.1016/j.jamcollsurg.2005.03.019. View