Salivary Biomarkers in Psychoneuroimmunology

Overview

Journal Curr Opin Behav Sci

Date 2020 Mar 28

PMID 32215283

Citations 25

Authors

Christopher G Engeland

Jos A Bosch

Nicolas Rohleder

Affiliations

Soon will be listed here.

Abstract

As molecular biology advances, an increasing number of proteins are becoming detectable at very low levels in different biological tissues. In this regard, saliva holds vast promise. Unlike blood, saliva can be sampled 1) non-invasively; 2) across all ages (newborn to elderly); 3) in the field; 4) by study participants; and 5) many times per day. With respect to psychoneuroimmunology (PNI), physiological measures of stress such as cortisol have been well characterized. Alpha amylase provides another physiological index of stress; it is a measure of autonomic nervous system activation and is quantifiable in saliva. Other salivary measures, such as inflammatory biomarkers and immunoglobulin A (IgA), provide valuable information pertaining to the effects of stress on inflammation, mucosal immunity, and oral health. Importantly, due to various methodological issues and a lack of strong correlation between saliva and blood measures, investigators should proceed with caution in drawing conclusions from measures of salivary inflammation that pertain to systemic immunity or generalized health.

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References

Auer B, Calvi J, Jordan N, Schrader D, Byrd-Craven J . Communication and social interaction anxiety enhance interleukin-1 beta and cortisol reactivity during high-stakes public speaking. Psychoneuroendocrinology. 2018; 94:83-90. DOI: 10.1016/j.psyneuen.2018.05.011. View

Kuras Y, McInnis C, Thoma M, Chen X, Hanlin L, Gianferante D . Increased alpha-amylase response to an acute psychosocial stress challenge in healthy adults with childhood adversity. Dev Psychobiol. 2016; 59(1):91-98. PMC: 5651411. DOI: 10.1002/dev.21470. View

Ouellet-Morin I, Danese A, Williams B, Arseneault L . Validation of a high-sensitivity assay for C-reactive protein in human saliva. Brain Behav Immun. 2011; 25(4):640-6. DOI: 10.1016/j.bbi.2010.12.020. View

Breines J, McInnis C, Kuras Y, Thoma M, Gianferante D, Hanlin L . Self-compassionate young adults show lower salivary alpha-amylase responses to repeated psychosocial stress. Self Identity. 2015; 14(4):390-402. PMC: 4437533. DOI: 10.1080/15298868.2015.1005659. View

Proctor G, Carpenter G . Chewing stimulates secretion of human salivary secretory immunoglobulin A. J Dent Res. 2001; 80(3):909-13. DOI: 10.1177/00220345010800031201. View

Sapolsky R, Romero L, Munck A . How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000; 21(1):55-89. DOI: 10.1210/edrv.21.1.0389. View

Nyklicek I, Bosch J, Nieuw Amerongen A . A generalized physiological hyperreactivity to acute stressors in hypertensives. Biol Psychol. 2005; 70(1):44-51. DOI: 10.1016/j.biopsycho.2004.11.013. View

Thomadaki K, Bosch J, Oppenheim F, Helmerhorst E . The diagnostic potential of salivary protease activities in periodontal health and disease. Oral Dis. 2013; 19(8):781-8. PMC: 3737350. DOI: 10.1111/odi.12069. View

Segerstrom S, Miller G . Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004; 130(4):601-30. PMC: 1361287. DOI: 10.1037/0033-2909.130.4.601. View

10.

Kaczor-Urbanowicz K, Carreras-Presas C, Aro K, Tu M, Garcia-Godoy F, Wong D . Saliva diagnostics - Current views and directions. Exp Biol Med (Maywood). 2016; 242(5):459-472. PMC: 5367650. DOI: 10.1177/1535370216681550. View

11.

Nagy T, van Lien R, Willemsen G, Proctor G, Efting M, Fulop M . A fluid response: Alpha-amylase reactions to acute laboratory stress are related to sample timing and saliva flow rate. Biol Psychol. 2015; 109:111-9. DOI: 10.1016/j.biopsycho.2015.04.012. View

12.

Siqueira E, de Souza F, Ferreira E, Souza R, Macedo S, Friedman E . Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva. J Oral Pathol Med. 2016; 45(9):682-686. DOI: 10.1111/jop.12434. View

13.

Gohel V, Jones J, Wehler C . Salivary biomarkers and cardiovascular disease: a systematic review. Clin Chem Lab Med. 2018; 56(9):1432-1442. DOI: 10.1515/cclm-2017-1018. View

14.

Rohleder N . Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom Med. 2014; 76(3):181-9. DOI: 10.1097/PSY.0000000000000049. View

15.

Sharma V, Gupta N, Srivastava N, Rana V, Chandna P, Yadav S . Diagnostic potential of inflammatory biomarkers in early childhood caries - A case control study. Clin Chim Acta. 2017; 471:158-163. DOI: 10.1016/j.cca.2017.05.037. View

16.

Dogan G, Toraman A, Sebin S, Dogan C, Gungor A, Aksoy H . Salivary IL-6 and IL-10 levels in subjects with obesity and gingivitis. Am J Dent. 2017; 29(5):261-265. View

17.

Couzin-Frankel J . Inflammation bares a dark side. Science. 2010; 330(6011):1621. DOI: 10.1126/science.330.6011.1621. View

18.

Yoon S, Weierich M . Salivary biomarkers of neural hypervigilance in trauma-exposed women. Psychoneuroendocrinology. 2015; 63:17-25. PMC: 4695293. DOI: 10.1016/j.psyneuen.2015.09.007. View

19.

Miller G, Rohleder N, Stetler C, Kirschbaum C . Clinical depression and regulation of the inflammatory response during acute stress. Psychosom Med. 2005; 67(5):679-87. DOI: 10.1097/01.psy.0000174172.82428.ce. View

20.

Bosch J, de Geus E, Kelder A, Veerman E, Hoogstraten J, Amerongen A . Differential effects of active versus passive coping on secretory immunity. Psychophysiology. 2001; 38(5):836-46. View