Alterations of Retinal Pigment Epithelium-Photoreceptor Complex in Patients with Type 2 Diabetes Mellitus Without Diabetic Retinopathy: A Cross-Sectional Study

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2020 Mar 28

PMID 32215275

Citations 8

Authors

Zheren Xia

Hao Chen

Suilian Zheng

Affiliations

Soon will be listed here.

Abstract

Aim: A cross-sectional study was performed to examine the alterations of the retinal pigment epithelium- (RPE-) photoreceptor complex layer in type 2 diabetes mellitus (DM) without diabetic retinopathy (DR), using spectral-domain optical coherence tomography (SD-OCT).

Methods: Patients with type 2 DM without DR and healthy controls without DM were recruited. All participants underwent examinations including SD-OCT. The thickness measurements of the retinal neural layers were calculated after automatic segmentation. An independent-sample -test was used to compare the means of the thickness of retinal neural layers in patients with DM and healthy controls.

Results: Sixty-seven eyes from 67 patients with DM and 30 eyes from 30 healthy controls were included in this study. No significant differences were found in age ( = 0.601), gender ( = 0.601), gender ( = 0.601), gender ( = 0.601), gender ( = 0.601), gender ( = 0.601), gender ( = 0.601), gender ( = 0.601), gender (.

Conclusion: Lesions in the RPE-photoreceptor complex are present without vascular abnormalities, which may precede the alterations of ganglion cells in patients with type 2 DM.

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