» Articles » PMID: 32213503

Preventive Measures to Avoid Vertical Transmission in Untreated Pregnant Women with HIV/AIDS

Overview
Journal BMJ Case Rep
Specialty General Medicine
Date 2020 Mar 28
PMID 32213503
Authors
Affiliations
Soon will be listed here.
Abstract

The HIV/AIDS during pregnancy has high morbidity and mortality, without optimal prevention and treatment. The advanced stage cases are found in developing countries due to late detection, but, also in developed countries due to immigration; therefore, the professionals should know the management steps for these patients. The implementation of specific interventions can reduce vertical transmission incidence until 1%-8%. It is presented a case of a pregnant woman with AIDS detected during first hospitalisation, due to a ventilatory failure by opportunistic germs; at the delivery the specific interventions were implemented, being able to eliminate vertical transmission to the newborn. This article explains the four main aspects to be considered for reducing vertical transmission (detection of HIV, viral load levels-CD4 lymphocyte count, way and moment of childbirth and antiretroviral therapy) and shares experiences of the management of an advanced case, in order to help professionals to handle these cases and its complications.

References
1.
Hurst S, Appelgren K, Kourtis A . Prevention of mother-to-child transmission of HIV type 1: the role of neonatal and infant prophylaxis. Expert Rev Anti Infect Ther. 2015; 13(2):169-81. PMC: 4470389. DOI: 10.1586/14787210.2015.999667. View

2.
Nesheim S, Harris L, Lampe M . Elimination of perinatal HIV infection in the USA and other high-income countries: achievements and challenges. Curr Opin HIV AIDS. 2013; 8(5):447-56. PMC: 4565151. DOI: 10.1097/COH.0b013e3283636ccb. View

3.
Gilleece D, Tariq D, Bamford D, Bhagani D, Byrne D, Clarke D . British HIV Association guidelines for the management of HIV in pregnancy and postpartum 2018. HIV Med. 2019; 20 Suppl 3:s2-s85. DOI: 10.1111/hiv.12720. View

4.
Peters H, Byrne L, de Ruiter A, Francis K, Harding K, Taylor G . Duration of ruptured membranes and mother-to-child HIV transmission: a prospective population-based surveillance study. BJOG. 2015; 123(6):975-81. DOI: 10.1111/1471-0528.13442. View

5.
Chetty T, Newell M, Thorne C, Coutsoudis A . Viraemia before, during and after pregnancy in HIV-infected women on antiretroviral therapy in rural KwaZulu-Natal, South Africa, 2010-2015. Trop Med Int Health. 2017; 23(1):79-91. PMC: 7612915. DOI: 10.1111/tmi.13001. View