Evaluation of the Andrographolides Role and Its Indoleamine 2,3-dioxygenase Inhibitory Potential and Attendant Molecular Mechanism Against STZ-induced Diabetic Rats

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2020 Mar 27

PMID 32210693

Citations 5

Authors

Munipally Praveen Kumar

Estari Mamidala

Khalid A Al-Ghanim

F Al-Misned

Shahid Mahboob

Affiliations

Soon will be listed here.

Abstract

The study is to scrutinize andrographolides with Indoleamine 2,3-dioxygenase (IDO) inhibitory potential, its molecular mechanism against streptozotocin (STZ) diabetic retinopathy (DR) in Wistar rats. Oxidative stress markers such as Kynurenine metabolites, retinal histopathological changes have been studied. Further, IDO gene expression and docking studies have been performed. Andrographolide treated rats have been reducing the level of thiobarbituric acid reactive substances and protein carbonyls Kynurenine metabolites with an improvement in the level of GSH and expression of IDO as revealed by morphological changes in inner and outer nuclear layer of the retina. The current results of this study have been generated information about an activity of the andrographolide in the essential pocket of IDO. Our results explain, involving IDO and andrographolide would constitute an attempt to identify natural products with therapeutic value and further studies in this direction would be of immense significance in the administration of diabetes and its related problems.

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