The Multifaceted Role of Kinases in Amyotrophic Lateral Sclerosis: Genetic, Pathological and Therapeutic Implications

Overview

Journal Brain

Publisher Oxford University Press

Specialty Neurology

Date 2020 Mar 25

PMID 32206784

Citations 26

Authors

Wenting Guo

Tijs Vandoorne

Jolien Steyaert

Kim A Staats

Ludo Van Den Bosch

Affiliations

Soon will be listed here.

Abstract

Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive at present will succumb to the disease. In recent years, numerous causative genes and risk factors for amyotrophic lateral sclerosis have been identified. Several of the recently identified genes encode kinases. In addition, the hypothesis that (de)phosphorylation processes drive the disease process resulting in selective motor neuron degeneration in different disease variants has been postulated. We re-evaluate the evidence for this hypothesis based on recent findings and discuss the multiple roles of kinases in amyotrophic lateral sclerosis pathogenesis. We propose that kinases could represent promising therapeutic targets. Mainly due to the comprehensive regulation of kinases, however, a better understanding of the disturbances in the kinome network in amyotrophic lateral sclerosis is needed to properly target specific kinases in the clinic.

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