Genetic Vulnerability to Opioid Addiction

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2020 Mar 25

PMID 32205416

Citations 4

Authors

Brian Reed

Mary Jeanne Kreek

Affiliations

Soon will be listed here.

Abstract

Opioid addiction, also referred to as opioid use disorder, continues to be a devastating problem throughout the world. Familial relation and twin studies have revealed opioid addiction, like other addictive diseases, to be profoundly influenced by genetics. Genetics studies of opioid addiction have affirmed the importance of genetics contributors in susceptibility to develop opioid addiction, and also have important implications on treatment for opioid addiction. But the complexity of the interactions of multiple genetic variants across diverse genes, as well as substantial differences in allelic frequencies across populations, thus far limits the predictive value of individual genetics variants.

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References

Olsen M, Jacobsen L, Schistad E, Pedersen L, Rygh L, Roe C . Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction. J Neurosci. 2012; 32(29):9831-4. PMC: 6621303. DOI: 10.1523/JNEUROSCI.1742-12.2012. View

Bart G, Heilig M, LaForge K, Pollak L, Leal S, Ott J . Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry. 2004; 9(6):547-9. PMC: 6141020. DOI: 10.1038/sj.mp.4001504. View

Frances F, Portoles O, Castello A, Costa J, Verdu F . Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. Bosn J Basic Med Sci. 2015; 15(2):31-6. PMC: 4469933. DOI: 10.17305/bjbms.2015.243. View

Szeto C, Tang N, Lee D, Stadlin A . Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts. Neuroreport. 2001; 12(6):1103-6. DOI: 10.1097/00001756-200105080-00011. View

Peles E, Levran O, Randesi M, Ott J, Kreek M, Adelson M . Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. J Addict Med. 2019; 13(6):430-435. DOI: 10.1097/ADM.0000000000000515. View

Kroslak T, LaForge K, Gianotti R, Ho A, Nielsen D, Kreek M . The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem. 2007; 103(1):77-87. DOI: 10.1111/j.1471-4159.2007.04738.x. View

Chong R, Oswald L, Yang X, Uhart M, Lin P, Wand G . The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress. Neuropsychopharmacology. 2005; 31(1):204-11. DOI: 10.1038/sj.npp.1300856. View

Koob G, Kreek M . Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007; 164(8):1149-59. PMC: 2837343. DOI: 10.1176/appi.ajp.2007.05030503. View

Chatti I, Woillard J, Mili A, Creveaux I, Ben Charfeddine I, Feki J . Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment. Iran J Public Health. 2017; 46(12):1704-1711. PMC: 5734971. View

10.

Mague S, Isiegas C, Huang P, Liu-Chen L, Lerman C, Blendy J . Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A. 2009; 106(26):10847-52. PMC: 2705603. DOI: 10.1073/pnas.0901800106. View

11.

Zhang Y, Picetti R, Butelman E, Ho A, Blendy J, Kreek M . Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice. Neuropsychopharmacology. 2014; 40(5):1091-100. PMC: 4367451. DOI: 10.1038/npp.2014.286. View

12.

Burns J, Kroll D, Feldman D, Kure Liu C, Manza P, Wiers C . Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders. Front Psychiatry. 2019; 10:626. PMC: 6759955. DOI: 10.3389/fpsyt.2019.00626. View

13.

Ding S, Chen B, Zheng Y, Lu Q, Liu L, Zhuge Q . Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population. BMC Psychiatry. 2013; 13:107. PMC: 3641981. DOI: 10.1186/1471-244X-13-107. View

14.

Bergen A, KOKOSZKA J, Peterson R, Long J, Virkkunen M, Linnoila M . Mu opioid receptor gene variants: lack of association with alcohol dependence. Mol Psychiatry. 1997; 2(6):490-4. DOI: 10.1038/sj.mp.4000331. View

15.

Coller J, Barratt D, Dahlen K, Loennechen M, Somogyi A . ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals. Clin Pharmacol Ther. 2006; 80(6):682-90. DOI: 10.1016/j.clpt.2006.09.011. View

16.

Tsuang M, Lyons M, Meyer J, Doyle T, Eisen S, Goldberg J . Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry. 1998; 55(11):967-72. DOI: 10.1001/archpsyc.55.11.967. View

17.

Gorman A, Elliott K, Inturrisi C . The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord. Neurosci Lett. 1997; 223(1):5-8. DOI: 10.1016/s0304-3940(97)13391-2. View

18.

Proudnikov D, Randesi M, Levran O, Crystal H, Dorn M, Ott J . Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment. J Infect Dis. 2012; 205(11):1745-56. PMC: 3415853. DOI: 10.1093/infdis/jis264. View

19.

Schluger J, Ho A, Borg L, Porter M, Maniar S, Gunduz M . Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: implications for the treatment of alcoholism. Alcohol Clin Exp Res. 1998; 22(7):1430-6. DOI: 10.1111/j.1530-0277.1998.tb03931.x. View

20.

Levran O, Peles E, Hamon S, Randesi M, Adelson M, Kreek M . CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. Addict Biol. 2011; 18(4):709-16. PMC: 3735354. DOI: 10.1111/j.1369-1600.2011.00349.x. View