A Powerful Combination of Copper-cysteamine Nanoparticles with Potassium Iodide for Bacterial Destruction

Overview

Journal Mater Sci Eng C Mater Biol Appl

Publisher Elsevier

Specialties Biomedical Engineering
Biotechnology

Date 2020 Mar 25

PMID 32204087

Citations 13

Authors

Xiumei Zhen

Lalit Chudal

Nil Kanatha Pandey

Jonathan Phan

Xin Ran

Eric Amador

Xuejing Huang

Omar Johnson

Yuping Ran

Wei Chen

Michael R Hamblin

Liyi Huang

Affiliations

Soon will be listed here.

Abstract

Herein, for the first time, we demonstrate that the combination of copper-cysteamine (Cu-Cy) nanoparticles (NPs) and potassium iodide (KI) can significantly inactivate both Gram-positive MRSA and Gram-negative E. coli. To uncover the mystery of the killing, the interaction of KI with Cu-Cy NPs was investigated systematically and the products from their interaction were identified. No copper ions were released after adding KI to Cu-Cy NPs in cell-free medium and, therefore, it is reasonable to conclude that the Fenton reaction induced by copper ions is not responsible for the bacterial killing. Based on the observations, we propose that the major killing mechanism involves the generation of toxic species, such as hydrogen peroxide, triiodide ions, iodide ions, singlet oxygen, and iodine molecules. Overall, the powerful combination of Cu-Cy NPs and KI has good potential as an independent treatment or a complementary antibiotic treatment to infectious diseases.

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References

Kenawy E, Worley S, Broughton R . The chemistry and applications of antimicrobial polymers: a state-of-the-art review. Biomacromolecules. 2007; 8(5):1359-84. DOI: 10.1021/bm061150q. View

Boyle R, Dolphin D . Structure and biodistribution relationships of photodynamic sensitizers. Photochem Photobiol. 1996; 64(3):469-85. DOI: 10.1111/j.1751-1097.1996.tb03093.x. View

Zhang Y, Dai T, Wang M, Vecchio D, Chiang L, Hamblin M . Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: in vitro and in vivo studies. Nanomedicine (Lond). 2015; 10(4):603-14. PMC: 4899971. DOI: 10.2217/nnm.14.131. View

Huang X, Wan F, Ma L, Phan J, Lim R, Li C . Investigation of copper-cysteamine nanoparticles as a new photosensitizer for anti-hepatocellular carcinoma. Cancer Biol Ther. 2019; 20(6):812-825. PMC: 6606015. DOI: 10.1080/15384047.2018.1564568. View

Dahl T, Midden W, Hartman P . Comparison of killing of gram-negative and gram-positive bacteria by pure singlet oxygen. J Bacteriol. 1989; 171(4):2188-94. PMC: 209876. DOI: 10.1128/jb.171.4.2188-2194.1989. View

Alias M, Alkhaldi N, Reguero M, Ma L, Zhang J, de Graaf C . Theoretical studies on the energy structures and optical properties of copper cysteamine - a novel sensitizer. Phys Chem Chem Phys. 2019; 21(37):21084-21093. PMC: 7439251. DOI: 10.1039/c9cp04392f. View

Yao M, Ma L, Li L, Zhang J, Lim R, Chen W . A New Modality for Cancer Treatment--Nanoparticle Mediated Microwave Induced Photodynamic Therapy. J Biomed Nanotechnol. 2018; 12(10):1835-51. DOI: 10.1166/jbn.2016.2322. View

Galdiero S, Falanga A, Cantisani M, Tarallo R, Della Pepa M, DOriano V . Microbe-host interactions: structure and role of Gram-negative bacterial porins. Curr Protein Pept Sci. 2013; 13(8):843-54. PMC: 3706956. DOI: 10.2174/138920312804871120. View

Nikaido H . Porins and specific diffusion channels in bacterial outer membranes. J Biol Chem. 1994; 269(6):3905-8. View

10.

Sandhu K, Gupta S . Potassium iodide remains the most effective therapy for cutaneous sporotrichosis. J Dermatolog Treat. 2003; 14(4):200-2. DOI: 10.1080/09546630310020452. View

11.

Nathwani D, Tillotson G . Vancomycin for Staphylococcus aureus therapy of respiratory tract infections: the end of an era?. Int J Antimicrob Agents. 2003; 21(6):521-4. DOI: 10.1016/s0924-8579(03)00046-3. View

12.

Mosinger J, MOSINGER B . Photodynamic sensitizers assay: rapid and sensitive iodometric measurement. Experientia. 1995; 51(2):106-9. DOI: 10.1007/BF01929349. View

13.

Huang L, Szewczyk G, Sarna T, Hamblin M . Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin. ACS Infect Dis. 2017; 3(4):320-328. PMC: 5528003. DOI: 10.1021/acsinfecdis.7b00004. View

14.

Van der Heijden J, Reynolds L, Deng W, Mills A, Scholz R, Imami K . Salmonella Rapidly Regulates Membrane Permeability To Survive Oxidative Stress. mBio. 2016; 7(4). PMC: 4992977. DOI: 10.1128/mBio.01238-16. View

15.

Minnock A, Vernon D, Schofield J, Griffiths J, Parish J, Brown S . Mechanism of uptake of a cationic water-soluble pyridinium zinc phthalocyanine across the outer membrane of Escherichia coli. Antimicrob Agents Chemother. 2000; 44(3):522-7. PMC: 89720. DOI: 10.1128/AAC.44.3.522-527.2000. View

16.

Fair R, Tor Y . Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014; 6:25-64. PMC: 4159373. DOI: 10.4137/PMC.S14459. View

17.

Ma L, Zou X, Chen W . A new X-ray activated nanoparticle photosensitizer for cancer treatment. J Biomed Nanotechnol. 2014; 10(8):1501-8. DOI: 10.1166/jbn.2014.1954. View

18.

Huang L, Xuan Y, Koide Y, Zhiyentayev T, Tanaka M, Hamblin M . Type I and Type II mechanisms of antimicrobial photodynamic therapy: an in vitro study on gram-negative and gram-positive bacteria. Lasers Surg Med. 2012; 44(6):490-9. PMC: 3428129. DOI: 10.1002/lsm.22045. View

19.

Spesia M, Durantini E . Photodynamic inactivation mechanism of Streptococcus mitis sensitized by zinc(II) 2,9,16,23-tetrakis[2-(N,N,N-trimethylamino)ethoxy]phthalocyanine. J Photochem Photobiol B. 2013; 125:179-87. DOI: 10.1016/j.jphotobiol.2013.06.007. View

20.

Ping J, Peng H, Qin J, You F, Wang Y, Chen G . A fluorescent nanoprobe for real-time monitoring of intracellular singlet oxygen during photodynamic therapy. Mikrochim Acta. 2018; 185(5):269. DOI: 10.1007/s00604-018-2815-5. View