Cu-catalyzed -3-Arylation of Hydantoins Using Diaryliodonium Salts

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2020 Mar 24

PMID 32202123

Citations 1

Authors

Linn Neerbye Berntsen

Ainara Nova

David S Wragg

Alexander H Sandtorv

Affiliations

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Abstract

A general Cu-catalyzed, regioselective method for the -3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.

Citing Articles

Recent Progress in Cyclic Aryliodonium Chemistry: Syntheses and Applications.

Peng X, Rahim A, Peng W, Jiang F, Gu Z, Wen S Chem Rev. 2023; .

PMID: 36649301 PMC: 9951228. DOI: 10.1021/acs.chemrev.2c00591.

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