Testing the Carbohydrate-insulin Model in Mice: The Importance of Distinguishing Primary Hyperinsulinemia from Insulin Resistance and Metabolic Dysfunction

Overview

Journal Mol Metab

Specialty Cell Biology

Date 2020 Mar 23

PMID 32199816

Citations 9

Authors

David S Ludwig

Cara B Ebbeling

Benjamin T Bikman

James D Johnson

Affiliations

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Citing Articles

The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet.

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Carbohydrate-insulin model: does the conventional view of obesity reverse cause and effect?.

Ludwig D Philos Trans R Soc Lond B Biol Sci. 2023; 378(1888):20220211.

PMID: 37661740 PMC: 10475871. DOI: 10.1098/rstb.2022.0211.

Testing the protein-leverage hypothesis using population surveillance data.

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The energy balance model of obesity: beyond calories in, calories out.

Hall K, Farooqi I, Friedman J, Klein S, Loos R, Mangelsdorf D Am J Clin Nutr. 2022; 115(5):1243-1254.

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The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.

Ludwig D, Aronne L, Astrup A, de Cabo R, Cantley L, Friedman M Am J Clin Nutr. 2021; 114(6):1873-1885.

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References

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Pawlak D, Kushner J, Ludwig D . Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet. 2004; 364(9436):778-85. DOI: 10.1016/S0140-6736(04)16937-7. View

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Torbay N, Bracco E, Geliebter A, Stewart I, Hashim S . Insulin increases body fat despite control of food intake and physical activity. Am J Physiol. 1985; 248(1 Pt 2):R120-4. DOI: 10.1152/ajpregu.1985.248.1.R120. View

Hu S, Wang L, Togo J, Yang D, Xu Y, Wu Y . The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice. Mol Metab. 2020; 32:27-43. PMC: 6938849. DOI: 10.1016/j.molmet.2019.11.010. View