The Quest to Identify the Mechanism Underlying Adrenergic Regulation of Cardiac Ca Channels

Overview

Journal Channels (Austin)

Specialty Biochemistry

Date 2020 Mar 21

PMID 32195622

Citations 6

Authors

Daniel Roybal

Jessica A Hennessey

Steven O Marx

Affiliations

Soon will be listed here.

Abstract

Activation of protein kinase A by cyclic AMP results in a multi-fold upregulation of Ca1.2 currents in the heart, as originally reported in the 1970's and 1980's. Despite considerable interest and much investment, the molecular mechanisms responsible for this signature modulation remained stubbornly elusive for over 40 years. A key manifestation of this lack of understanding is that while this regulation is readily apparent in heart cells, it has not been possible to reconstitute it in heterologous expression systems. In this review, we describe the efforts of many investigators over the past decades to identify the mechanisms responsible for the β-adrenergic mediated activation of voltage-gated Ca channels in the heart and other tissues.

Citing Articles

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