MicroRNAs Association with Azoospermia, Oligospermia, Asthenozoospermia, and Teratozoospermia: a Systematic Review

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2020 Mar 20

PMID 32189180

Citations 12

Authors

Yousef Daneshmandpour

Zahra Bahmanpour

Hamid Hamzeiy

Marziyeh Mazaheri Moghaddam

Madiheh Mazaheri Moghaddam

Bahareh Khademi

Ebrahim Sakhinia

Affiliations

Soon will be listed here.

Abstract

Infertility is a major health problem across the world. One of the main reasons for male infertility are defects in sperm. Semen analysis is the most common test utilized to evaluate male fertility and since it suffers from multiple drawbacks, reproduction scientists have tried to find new molecular markers for detecting sperm defects. MicroRNAs (miRNAs) are small molecules in cells which take part in regulating gene expression. Various studies have confirmed miRNAs to have a role in defining multiple sperm characteristics, including sperm count, motility, and morphology. In this paper, we have systematically reviewed the role of miRNAs in infertile men with sperm defects including azoospermia, oligospermia, asthenozoospermia, and teratozoospermia. Also, we have assembled various bioinformatics tools to come up with a pipeline for predicting novel miRNAs which could possibly participate in sperm count, motility, and morphology. Also, related KEGG and GO terms for predicted miRNAs have been included in order to highlight their role in sperm function. Our study emphasizes the potential role of miRNAs in male infertility and provides a general overview for future studies aiming to find robust molecular markers for this condition.

Citing Articles

Exploring miR-34a, miR-449, and ADAM2/ADAM7 Expressions as Potential Biomarkers in Male Infertility: A Combined In Silico and Experimental Approach.

Ghodrati F, Parivar K, Amiri I, Roodbari N Biochem Genet. 2025; .

PMID: 39928278 DOI: 10.1007/s10528-025-11050-1.

Circulating microRNAs in Body Fluid: "Fingerprint" RNA Snippets Deeply Impact Reproductive Biology.

Mukherjee A, Verma A, Das T, Ghosh B, Ghosh Z Reprod Sci. 2024; 32(3):555-574.

PMID: 39658771 DOI: 10.1007/s43032-024-01753-y.

The role of p53 in male infertility.

Li J, Huang X, Luo L, Sun J, Guo Q, Yang X Front Endocrinol (Lausanne). 2024; 15:1457985.

PMID: 39469578 PMC: 11513281. DOI: 10.3389/fendo.2024.1457985.

Characterizing the Impact of Dysregulated Micrornas on CRISP3 Isoforms in Male Infertility.

Gholami D, Amirmahani F, Yazdi R, Nemati-Dehkordi M, Teimori H Reprod Sci. 2024; 31(12):3768-3778.

PMID: 39407057 DOI: 10.1007/s43032-024-01703-8.

Possible involvement of a MEG3-miR-21-SPRY1-NF-κB feedback loop in spermatogenic cells proliferation, autophagy, and apoptosis.

Fang X, Lu X, Ma Y, Sun N, Jiao Y, Meng H iScience. 2024; 27(10):110904.

PMID: 39398251 PMC: 11467676. DOI: 10.1016/j.isci.2024.110904.

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