A Comparison of Cytotoxic Effects of L. and Extract on Human Chronic Lymphocytic Leukemia

Overview

Journal Iran J Pharm Res

Publisher Brieflands

Specialty Pharmacology

Date 2020 Mar 19

PMID 32184851

Citations 1

Authors

Abdollmajid Ayatollahi

Jalil Rahmati

Ahmad Salimi

Jalal Pourahmad

Affiliations

Soon will be listed here.

Abstract

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango ( L.) and are thought to be rich of functional phytochemicals. To clarify the anticancer activity, aqueous extracts of nut and fruit were exanimated on chronic lymphocytic leukemia (CLL) B lymphocytes and their mitochondria and the results were compared with those of normal B lymphocytes. Cellular parameters such as viability and caspase 3 activity, and mitochondrial parameters such as reactive oxygen species (ROS), mitochondria membrane potential (MMP), mitochondrial swelling, and cytochrome c release were evaluated. Our results demonstrated that the extract of L increased cytotoxicity and caspase 3 activation through mitochondria pathway only in CLL B lymphocytes and also the extract of did not show cytotoxicity and caspase 3 activation on CLL and healthy B lymphocytes. Our findings on isolated mitochondria indicated that mitochondrial ROS formation, MMP collapse, and mitochondrial swelling and cytochrome c release were significantly ( < 0.05) increased after addition of only in cancerous mitochondria. These results demonstrated that can act as a promising source for anti-cancer drug candidates by directly and selectively targeting mitochondria and inducing selective mitochondria mediated apoptosis on CLL B lymphocytes.

Citing Articles

Mangiferin: An effective agent against human malignancies.

Irshad N, Naeem H, Shahbaz M, Imran M, Mujtaba A, Hussain M Food Sci Nutr. 2024; 12(10):7137-7157.

PMID: 39479608 PMC: 11521646. DOI: 10.1002/fsn3.4434.

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