The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis

Overview

Journal Animals (Basel)

Date 2020 Mar 19

PMID 32183497

Citations 10

Authors

Laura Menchetti

Giulio Curone

Iulia Elena Filipescu

Olimpia Barbato

Leonardo Leonardi

Gabriella Guelfi

Giovanna Traina

Patrizia Casagrande-Proietti

Federica Riva

Anna Beatrice Casano

Federica Piro

Daniele Vigo

Alda Quattrone

Gabriele Brecchia

Affiliations

Soon will be listed here.

Abstract

This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12) administration in mice. Clinical signs, histopathological characteristics, expression levels of Toll-like receptor 4 (TLR4), pro- and anti-inflammatory cytokines, and microbial composition were assessed. BC was well tolerated and did not induce any histological damage or clinical symptoms. After TNBS treatment, the BC group showed a reduction in body weight (BW) loss compared to Control ( < 0.05). Moreover, expression levels of TLR4 ( < 0.01), Interleukin-1β (IL-1β; < 0.001), Interleukin-8 (IL-8; < 0.001), and Interleukin-10 (IL-10; < 0.001) were lower in mice administered with BC. Finally, were higher ( < 0.05), while Enterococci ( < 0.001), spp. ( < 0.001), and spp. ( < 0.05) were lower in Control than BC group. This study confirms that pre-treatment with BC modulates the expression of genes and the count of microbes involved in the etiopathogenesis of colitis.

Citing Articles

Antioxidant Activity of Bovine Colostrum in the Colon of a Mouse Model of TNBS-Induced Colitis.

Leonardi L, Dib S, Costanzi E, Brecchia G, Traina G Antioxidants (Basel). 2025; 14(2).

PMID: 40002416 PMC: 11852126. DOI: 10.3390/antiox14020232.

Effects of Chicken Egg Powder, Bovine Colostrum, and Combination Therapy for the Treatment of Gastrointestinal Disorders.

Playford R Nutrients. 2024; 16(21).

PMID: 39519517 PMC: 11547998. DOI: 10.3390/nu16213684.

Bovine Colostrum Supplementation in Rabbit Diet Modulates Gene Expression of Cytokines, Gut-Vascular Barrier, and Red-Ox-Related Molecules in the Gut Wall.

Riva F, Draghi S, Inglesi A, Filipe J, Cremonesi P, Lavazza A Animals (Basel). 2024; 14(5).

PMID: 38473185 PMC: 10930591. DOI: 10.3390/ani14050800.

Intestine Health and Barrier Function in Fattening Rabbits Fed Bovine Colostrum.

Aidos L, Pallaoro M, Mirra G, Serra V, Castrica M, Agradi S Vet Sci. 2023; 10(11).

PMID: 37999480 PMC: 10675739. DOI: 10.3390/vetsci10110657.

Colostrum Quality in Different Goat Breeds Reared in Northern Italy.

Agradi S, Gonzalez-Cabrera M, Arguello A, Hernandez-Castellano L, Castro N, Menchetti L Animals (Basel). 2023; 13(19).

PMID: 37835753 PMC: 10571944. DOI: 10.3390/ani13193146.

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