Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2020 Mar 19

PMID 32183102

Citations 40

Authors

Lei Yin

Xiaotian Liu

Yinghong Shi

Dickson Kofi Wiredu Ocansey

Yuyan Hu

Xiaoxi Li

Chenxiao Zhang

Wenrong Xu

Hui Qian

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.

Citing Articles

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