The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders

Overview

Journal J Clin Med

Specialty General Medicine

Date 2020 Mar 19

PMID 32182899

Citations 92

Authors

Sonia Missiroli

Ilaria Genovese

Mariasole Perrone

Bianca Vezzani

Veronica A M Vitto

Carlotta Giorgi

Affiliations

Soon will be listed here.

Abstract

The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflammatory signaling, identifying these organelles as a central platform for the control of innate immunity and the inflammatory response. Thus, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Strategies aimed at reestablishing normal mitochondrial physiology could represent both preventive and therapeutic interventions for various pathologies related to exacerbated inflammation. Here, we explore the current understanding of the intricate interplay between mitochondria and the innate immune response in specific inflammatory diseases, such as neurological disorders and cancer.

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