Synthesis and Herbicidal Activities of Aryloxyacetic Acid Derivatives As HPPD Inhibitors

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2020 Mar 18

PMID 32180842

Citations 3

Authors

Man-Man Wang

Hao Huang

Lei Shu

Jian-Min Liu

Jian-Qiu Zhang

Yi-le Yan

Da-Yong Zhang

Affiliations

Soon will be listed here.

Abstract

A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising HPPD (HPPD) inhibitors, in particular compounds ( = 0.011 µM) and ( = 0.012 µM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide ( = 0.013 µM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition, compound was safe for weed control in maize fields at a rate of 150 g ai/ha, and was identified as the most potent candidate for a novel HPPD inhibitor herbicide. The compounds described herein may provide useful guidance for the design of new HPPD inhibiting herbicides and their modification.

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