Inflammation in Traumatic Brain Injury

Overview

Journal J Alzheimers Dis

Publisher Sage Publications

Specialties Geriatrics
Neurology

Date 2020 Mar 17

PMID 32176646

Citations 32

Authors

Teodor T Postolache

Abhishek Wadhawan

Adem Can

Christopher A Lowry

Margaret Woodbury

Hina Makkar

Andrew J Hoisington

Alison J Scott

Eileen Potocki

Michael E Benros

John W Stiller

Affiliations

Soon will be listed here.

Abstract

There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.

Citing Articles

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies.

Mallick R, Basak S, Chowdhury P, Bhowmik P, Das R, Banerjee A Pharmaceuticals (Basel). 2025; 18(1).

PMID: 39861166 PMC: 11769149. DOI: 10.3390/ph18010104.

Severity of Repetitive Mild Traumatic Brain Injury Depends on Microglial Heme Oxygenase-1 and Carbon Monoxide.

Kaiser S, Fritsch A, Jakob L, Schallner N Eur J Neurosci. 2025; 61(2):e16666.

PMID: 39844588 PMC: 11755003. DOI: 10.1111/ejn.16666.

Agathisflavone Modulates Reactive Gliosis After Trauma and Increases the Neuroblast Population at the Subventricular Zone.

Castro E Silva J, Pieropan F, Rivera A, Butt A, Costa S Nutrients. 2024; 16(23).

PMID: 39683446 PMC: 11642973. DOI: 10.3390/nu16234053.

The Role of Neuroinflammation in Shaping Neuroplasticity and Recovery Outcomes Following Traumatic Brain Injury: A Systematic Review.

Calderone A, Latella D, Cardile D, Gangemi A, Corallo F, Rifici C Int J Mol Sci. 2024; 25(21).

PMID: 39519259 PMC: 11546226. DOI: 10.3390/ijms252111708.

Inflammation and olfactory loss are associated with at least 139 medical conditions.

Leon M, Troscianko E, Woo C Front Mol Neurosci. 2024; 17:1455418.

PMID: 39464255 PMC: 11502474. DOI: 10.3389/fnmol.2024.1455418.

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