Chondrosarcomas in Children and Adolescents

Overview

Journal EFORT Open Rev

Specialty Orthopedics

Date 2020 Mar 17

PMID 32175095

Citations 5

Authors

Ajay Puri

Affiliations

Soon will be listed here.

Abstract

Chondrosarcomas in children and adolescents are uncommon and constitute < 5% of all chondrosarcomas. There are very few studies discussing extremity chondrosarcomas in young patients.The pelvis is the most common site, followed by the proximal femur.As cartilaginous tumours can be quite challenging to diagnose, it is best for these lesions to be discussed in a multidisciplinary meeting which includes a radiologist and a pathologist specializing in bone tumours.Treatment principles are similar to those in adults, with adequate surgical excision respecting oncologic principles being the mainstay of treatment. Select extremity Grade I chondrosarcomas may be managed with extended intralesional curettage without increasing the risk for local recurrence or metastatic disease, but case selection is critical and should be based on clinical, imaging and histological characteristics.Chondrosarcomas are resistant to chemotherapy and relatively radioresistant. For mesenchymal chondrosarcomas, there may be a role for chemotherapy, though data on this is limited.Prognosis and rate of recurrence correlate directly to the adequacy of the surgical resection.Chondrosarcomas in younger patients behave in a similar fashion to those in adults, and outcomes in the young are no different from those in adults. Cite this article: 2020;5:90-95. DOI: 10.1302/2058-5241.5.190052.

Citing Articles

Application direct anterior approach in pediatric femoral head and neck lesions.

Zheng J, Zhang Y, Nan G J Orthop Surg Res. 2024; 19(1):233.

PMID: 38600584 PMC: 11005179. DOI: 10.1186/s13018-024-04721-z.

Extraskeletal conventional chondrosarcoma of genitalia in a child- An unusual pathology for a rare tumor.

Ebrahimisaraj G, Alavi S, Kazemi Aghdam M, Khalili M, Khaffafpour Z, Ebrahimian M Int J Surg Case Rep. 2024; 115:109230.

PMID: 38237415 PMC: 10828804. DOI: 10.1016/j.ijscr.2024.109230.

Patient-Derived Spheroid Culture Models Are Better Than Monolayer Models in Chondrosarcoma Research.

Ma R, Heim T, Schoedel K, Weiss K Res Sq. 2024; .

PMID: 38168175 PMC: 10760310. DOI: 10.21203/rs.3.rs-3728259/v1.

Magnetic Resonance Imaging Features and Prognostic Indicators of Local Recurrence after Curettage and Cementation of Atypical Cartilaginous Tumour in the Appendicular Skeleton.

Ardakani A, Morgan R, Matheron G, Havard H, Khoo M, Saifuddin A J Clin Med. 2023; 12(21).

PMID: 37959370 PMC: 10649515. DOI: 10.3390/jcm12216905.

Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions.

Gilbert A, Tudor M, Montanari J, Commenchail K, Savu D, Lesueur P Cancers (Basel). 2023; 15(7).

PMID: 37046623 PMC: 10093143. DOI: 10.3390/cancers15071962.

References

Winkelmann W . Type-B-IIIa hip rotationplasty: an alternative operation for the treatment of malignant tumors of the femur in early childhood. J Bone Joint Surg Am. 2000; 82(6):814-28. DOI: 10.2106/00004623-200006000-00008. View

Purandare N, Puranik A, Shah S, Agrawal A, Puri A, Gulia A . Can 18F-FDG PET/CT diagnose malignant change in benign chondroid tumors?. Nucl Med Commun. 2019; 40(6):645-651. DOI: 10.1097/MNM.0000000000001015. View

Bishop M, Somerville J, Bahrami A, Kaste S, Interiano R, Wu J . Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review. Sarcoma. 2015; 2015:608279. PMC: 4469840. DOI: 10.1155/2015/608279. View

Puri A, Gulia A . Paediatric diaphyseal malignant tumors: options for reconstruction after intercalary resection. J Pediatr Orthop B. 2011; 20(5):309-17. DOI: 10.1097/BPB.0b013e3283456519. View

Mosier S, Patel T, Strenge K, Mosier A . Chondrosarcoma in childhood: the radiologic and clinical conundrum. J Radiol Case Rep. 2013; 6(12):32-42. PMC: 3557123. DOI: 10.3941/jrcr.v6i12.1241. View

Herget G, Kontny U, Saueressig U, Baumhoer D, Hauschild O, Elger T . [Osteochondroma and multiple osteochondromas: recommendations on the diagnostics and follow-up with special consideration to the occurrence of secondary chondrosarcoma]. Radiologe. 2013; 53(12):1125-36. DOI: 10.1007/s00117-013-2571-9. View

Gulia A, Puri A, Byregowda S . Staging investigations in chondrosarcoma: Is evaluation for skeletal metastases justified? Analysis from an epidemiological study at a tertiary cancer care center and review of literature. South Asian J Cancer. 2016; 5(1):3-4. PMC: 4845606. DOI: 10.4103/2278-330X.179690. View

Serlo J, Tarkkanen M, Sampo M, Vettenranta K, Riikonen P, Helenius I . Incidence, treatment and survival of paediatric patients with bone sarcomas in Finland from 1991 to 2005. Acta Paediatr. 2015; 104(7):738-45. DOI: 10.1111/apa.12986. View

Nooij M, Whelan J, Bramwell V, Taminiau A, Cannon S, Hogendoorn P . Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. Eur J Cancer. 2005; 41(2):225-30. DOI: 10.1016/j.ejca.2004.08.026. View

10.

DABSKA M, Huvos A . Mesenchymal chondrosarcoma in the young. Virchows Arch A Pathol Anat Histopathol. 1983; 399(1):89-104. DOI: 10.1007/BF00666221. View

11.

van Kampen M, Grimer R, Carter S, Tillman R, Abudu A . Replacement of the hip in children with a tumor in the proximal part of the femur. J Bone Joint Surg Am. 2008; 90(4):785-95. DOI: 10.2106/JBJS.F.01182. View

12.

Fukushima T, Ogura K, Akiyama T, Takeshita K, Kawai A . Descriptive epidemiology and outcomes of bone sarcomas in adolescent and young adult patients in Japan. BMC Musculoskelet Disord. 2018; 19(1):297. PMC: 6098838. DOI: 10.1186/s12891-018-2217-1. View

13.

Stevenson J, Laitinen M, Parry M, Sumathi V, Grimer R, Jeys L . The role of surgical margins in chondrosarcoma. Eur J Surg Oncol. 2018; 44(9):1412-1418. DOI: 10.1016/j.ejso.2018.05.033. View

14.

Gelderblom H, Hogendoorn P, Dijkstra S, van Rijswijk C, Krol A, Taminiau A . The clinical approach towards chondrosarcoma. Oncologist. 2008; 13(3):320-9. DOI: 10.1634/theoncologist.2007-0237. View

15.

Fujiwara T, Lex J, Stevenson J, Tsuda Y, Clark R, Parry M . Surgical treatment for pelvic Ewing sarcoma: What is a safe and functional acetabular reconstruction when combined with modern multidisciplinary treatments?. J Surg Oncol. 2019; 120(6):985-993. DOI: 10.1002/jso.25660. View

16.

Herget G, Strohm P, Rottenburger C, Kontny U, Krauss T, Bohm J . Insights into Enchondroma, Enchondromatosis and the risk of secondary Chondrosarcoma. Review of the literature with an emphasis on the clinical behaviour, radiology, malignant transformation and the follow up. Neoplasma. 2014; 61(4):365-78. DOI: 10.4149/neo_2014_046. View

17.

Fiorenza F, Abudu A, Grimer R, Carter S, Tillman R, Ayoub K . Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br. 2002; 84(1):93-9. DOI: 10.1302/0301-620x.84b1.11942. View

18.

Aprin H, RISEBOROUGH E, Hall J . Chondrosarcoma in children and adolescents. Clin Orthop Relat Res. 1982; (166):226-32. View

19.

Zamora T, Urrutia J, Schweitzer D, Amenabar P, Botello E . Do Orthopaedic Oncologists Agree on the Diagnosis and Treatment of Cartilage Tumors of the Appendicular Skeleton?. Clin Orthop Relat Res. 2017; 475(9):2176-2186. PMC: 5539017. DOI: 10.1007/s11999-017-5276-y. View

20.

Gambarotti M, Righi A, Picci P, Bertoni F, Manfrini M, Donati D . Paediatric chondrosarcomas: a retrospective review of 17 cases. Histopathology. 2015; 68(7):1073-8. DOI: 10.1111/his.12881. View