Profile of Infectious and Sterile Keratitis After Accelerated Corneal Collagen Cross-linking for Keratoconus

Overview

Journal Oman J Ophthalmol

Specialty Ophthalmology

Date 2020 Mar 17

PMID 32174735

Citations 5

Authors

Shreesha Kumar Kodavoor

Nitin Narendra Tiwari

Dandapani Ramamurthy

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to assess the potential risk factors and causes of infectious and sterile keratitis after accelerated collagen cross-linking.

Methods: Case records of 968 eyes that underwent accelerated corneal collagen cross-linking (ACXL) over the period of 4 years were reviewed retrospectively. ACXL was done using (Avedro KXL system, Waltham, MA, USA) 9 mW/cm for 10 min protocol providing total energy of 5.4 J/cm.

Results: Of 968 eyes, a total of three eyes developed infectious keratitis and seven eyes developed sterile infiltrates. Three of this infectious keratitis had two cases which were resistant to fourth-generation fluoroquinolones. Seven cases of sterile infiltrates had excellent resolution after treatment with topical steroids. Sterile infiltrates were common in corneas with thinnest pachymetry of <400 µm, except in one case of intra stromal corneal ring segments (INTACS) + ACXL.

Conclusion: Judicious use of steroids in the initial postoperative period is recommended so as to prevent any form of microbial keratitis. Very steep corneas and too thin corneas should be looked with high index of suspicion in view of chances of developing sterile infiltrates.

Citing Articles

Outcomes of pediatric sterile keratitis posthypotonic collagen cross-linking.

Kaur A, Sahu S, Garg P, Roy A Oman J Ophthalmol. 2024; 17(3):376-379.

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Comparison of Efficacy and Safety Between Standard, Accelerated Epithelium-Off and Transepithelial Corneal Collagen Crosslinking in Pediatric Keratoconus: A Meta-Analysis.

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Retrospective Analysis of Sterile Corneal Infiltrates in Patients with Keratoconus after Cross-Linking Procedure.

Krok M, Wroblewska-Czajka E, Kokot J, Micinska A, Wylegala E, Dobrowolski D J Clin Med. 2022; 11(3).

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Infectious keratitis after corneal crosslinking for keratoconus caused by levofloxacin-resistant microorganisms.

Kato N, Ide T, Kobashi H, Toda I BMC Ophthalmol. 2021; 21(1):317.

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Wu D, Lim D, Lim B, Wong N, Hafezi F, Manotosh R Front Pharmacol. 2021; 12:686630.

PMID: 34349648 PMC: 8326410. DOI: 10.3389/fphar.2021.686630.

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