Vitamin D and Connective Tissue Diseases

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2020 Mar 16

PMID 32172354

Citations 6

Authors

Stefano Berardi

Liberato Giardullo

Addolorata Corrado

Francesco Paolo Cantatore

Affiliations

Soon will be listed here.

Abstract

Objective And Design: Recently, many studies have shown that the biologically active form of vitamin D-1,25(OH) D-is involved in many biological processes, including immune system modulation, and patients affected by various autoimmune diseases, such as connective tissue diseases (CTD), showed low levels of vitamin D. It is not clear if vitamin D deficiency is involved in the pathogenesis of autoimmune diseases or it is a consequence.

Material: We carried out a review of literature to summarize the existing connections between 25-OH vitamin D and CTD.

Methods: We searched for articles on PubMed by keywords: vitamin D, connective tissue diseases, systemic lupus erythematosus, Sjogren's syndrome, systemic sclerosis, undifferentiated connective tissue disease.

Results: The relationship between vitamin D and CTD is still not very clear, despite many studies having been performed and some data suggest a connection between these diseases and 25-OH vitamin D levels.

Conclusions: The limitations of the study, such as the heterogeneity of patients, methods used to measure vitamin D serum concentration and other biases, do not lead to unequivocal results to demonstrate a direct link between low vitamin D serum levels and autoimmune diseases. Further studies are needed to resolve conflicting results.

Citing Articles

Vitamin D and Sjögren's Disease: Revealing the Connections-A Systematic Review and Meta-Analysis.

Radic M, Kolak E, dogas H, Gelemanovic A, Nenadic D, Vuckovic M Nutrients. 2023; 15(3).

PMID: 36771203 PMC: 9920259. DOI: 10.3390/nu15030497.

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases.

Sirbe C, Rednic S, Grama A, Pop T Int J Mol Sci. 2022; 23(17).

PMID: 36077185 PMC: 9456003. DOI: 10.3390/ijms23179784.

The Clinical Significance of Vitamin D and Zinc Levels with Respect to Immune Response in COVID-19 Positive Children.

Dogan A, Dumanoglu Dogan I, Uyanik M, Kole M, Pismisoglu K J Trop Pediatr. 2022; 68(5).

PMID: 35994727 PMC: 9452162. DOI: 10.1093/tropej/fmac072.

1,25OH-Vitamin D3 and IL-17 Inhibition Modulate Pro-Fibrotic Cytokines Production in Peripheral Blood Mononuclear Cells of Patients with Systemic Sclerosis.

Corrado A, Rotondo C, Sanpaolo E, Altomare A, Maruotti N, Cici D Int J Med Sci. 2022; 19(5):867-877.

PMID: 35693738 PMC: 9149638. DOI: 10.7150/ijms.70984.

Diet in Scleroderma: Is There a Need for Intervention?.

Burlui A, Cardoneanu A, Macovei L, Rezus C, Boiculese L, Graur M Diagnostics (Basel). 2021; 11(11).

PMID: 34829464 PMC: 8620611. DOI: 10.3390/diagnostics11112118.

References

Tuder R, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y . Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol. 2001; 195(3):367-74. DOI: 10.1002/path.953. View

Szodoray P, Nakken B, Barath S, Gaal J, Aleksza M, Zeher M . Progressive divergent shifts in natural and induced T-regulatory cells signify the transition from undifferentiated to definitive connective tissue disease. Int Immunol. 2008; 20(8):971-9. DOI: 10.1093/intimm/dxn056. View

Caimmi C, Bertoldo E, Pozza A, Caramaschi P, Orsolini G, Gatti D . Vitamin D serum levels and the risk of digital ulcers in systemic sclerosis: A longitudinal study. Int J Rheum Dis. 2019; 22(6):1041-1045. DOI: 10.1111/1756-185X.13554. View

Kiani A, Fang H, Magder L, Petri M . Vitamin D deficiency does not predict progression of coronary artery calcium, carotid intima-media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus. Rheumatology (Oxford). 2013; 52(11):2071-6. PMC: 3798716. DOI: 10.1093/rheumatology/ket271. View

Mok C, Birmingham D, Leung H, Hebert L, Song H, Rovin B . Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis. Rheumatology (Oxford). 2011; 51(4):644-52. DOI: 10.1093/rheumatology/ker212. View

Mazzaferro S, Pasquali M . Vitamin D: a dynamic molecule. How relevant might the dynamism for a vitamin be?. Nephrol Dial Transplant. 2015; 31(1):23-30. DOI: 10.1093/ndt/gfv340. View

Kendrick J, Targher G, Smits G, Chonchol M . 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis. 2008; 205(1):255-60. DOI: 10.1016/j.atherosclerosis.2008.10.033. View

Cantorna M, Mahon B . Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004; 229(11):1136-42. DOI: 10.1177/153537020422901108. View

Carlberg C, Haq A . The concept of the personal vitamin D response index. J Steroid Biochem Mol Biol. 2016; 175:12-17. DOI: 10.1016/j.jsbmb.2016.12.011. View

10.

Kamen D, Aranow C . The link between vitamin D deficiency and systemic lupus erythematosus. Curr Rheumatol Rep. 2008; 10(4):273-80. DOI: 10.1007/s11926-008-0044-3. View

11.

Penna G, Amuchastegui S, Giarratana N, Daniel K, Vulcano M, Sozzani S . 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J Immunol. 2006; 178(1):145-53. DOI: 10.4049/jimmunol.178.1.145. View

12.

Giovannucci E, Liu Y, Hollis B, Rimm E . 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008; 168(11):1174-80. PMC: 3719391. DOI: 10.1001/archinte.168.11.1174. View

13.

Bischoff H, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin H . In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001; 33(1):19-24. DOI: 10.1023/a:1017535728844. View

14.

Groseanu L, Bojinca V, Gudu T, Saulescu I, Predeteanu D, Balanescu A . Low vitamin D status in systemic sclerosis and the impact on disease phenotype. Eur J Rheumatol. 2016; 3(2):50-55. PMC: 5042230. DOI: 10.5152/eurjrheum.2015.0065. View

15.

Cutillas-Marco E, Morales-Suarez-Varela M, Marquina-Vila A, Grant W . Serum 25-hydroxyvitamin D levels in patients with cutaneous lupus erythematosus in a Mediterranean region. Lupus. 2010; 19(7):810-4. PMC: 2876867. DOI: 10.1177/0961203309360807. View

16.

Sandhya P, Mahasampath G, Mashru P, Bondu J, Job V, Danda D . Vitamin D Levels and Associations in Indian Patients with Primary Sjögren's Syndrome. J Clin Diagn Res. 2017; 11(9):OC33-OC36. PMC: 5713779. DOI: 10.7860/JCDR/2017/28493.10697. View

17.

DeLuca H, Cantorna M . Vitamin D: its role and uses in immunology. FASEB J. 2001; 15(14):2579-85. DOI: 10.1096/fj.01-0433rev. View

18.

Prietl B, Treiber G, Pieber T, Amrein K . Vitamin D and immune function. Nutrients. 2013; 5(7):2502-21. PMC: 3738984. DOI: 10.3390/nu5072502. View

19.

Zerr P, Vollath S, Palumbo-Zerr K, Tomcik M, Huang J, Distler A . Vitamin D receptor regulates TGF-β signalling in systemic sclerosis. Ann Rheum Dis. 2014; 74(3):e20. DOI: 10.1136/annrheumdis-2013-204378. View

20.

Chizzolini C, Cohen C, Eisenberger U, Hauser T, Hunziker T, Leimgruber A . [Towards the Swiss systemic lupus erythematosus cohort study (SSCS)]. Rev Med Suisse. 2009; 5(199):808-11. View