Prenatal Antidepressant Exposures and Gastrointestinal Complaints in Childhood: A Gut-brain Axis Connection?

Overview

Journal Dev Psychobiol

Specialties Pediatrics
Psychiatry
Psychology

Date 2020 Mar 14

PMID 32167584

Citations 9

Authors

Amy L Salisbury

George D Papandonatos

Laura R Stroud

Alicia K Smith

Patricia A Brennan

Affiliations

Soon will be listed here.

Abstract

Selective serotonin/norepinephrine reuptake inhibitors (collectively, SRIs) are the most commonly prescribed antidepressant agents for the treatment of depression in pregnancy. SRIs affect maternal and placental serotonin signaling, which might impact fetal brain development. Alterations in serotonin signaling might also impact the developing gut-brain axis (GBA) via alterations in the fetal enteric nervous system (ENS). Emerging evidence suggests that gestational SRI exposure may be associated with offspring gastrointestinal problems. However, prospective human studies of the effects of fetal SRI exposure on the ENS and function are absent in the literature. In this paper we present data demonstrating significant associations between prenatal SRI exposure and children's gastrointestinal (GI) problems in two well-characterized, prospective cohorts of preschool and later childhood individuals. The results support the hypothesis that prenatal SRI exposure can increase the risk for childhood GI difficulties. Further research is warranted on the potential SRI-induced changes to the child gut including the role of the microbiome and the GBA in the development of GI problems.

Citing Articles

Prenatal exposure to selective serotonin reuptake inhibitors and risk of disorders of gut-brain interaction in children.

Kildegaard H, Bliddal M, Ernst M, Sander S, Wesselhoeft R, Gingrich J Mol Psychiatry. 2024; .

PMID: 39658704 DOI: 10.1038/s41380-024-02848-3.

Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.

Najjar S, Hung L, Margolis K Compr Physiol. 2023; 13(3):4851-4868.

PMID: 37358510 PMC: 10373054. DOI: 10.1002/cphy.c220024.

The role of gut microbiota in depression: an analysis of the gut-brain axis.

Irum N, Afzal T, Faraz M, Aslam Z, Rasheed F Front Behav Neurosci. 2023; 17:1185522.

PMID: 37333479 PMC: 10272349. DOI: 10.3389/fnbeh.2023.1185522.

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression.

Doroftei B, Ilie O, Diaconu R, Hutanu D, Stoian I, Ilea C Diagnostics (Basel). 2022; 12(7).

PMID: 35885482 PMC: 9315700. DOI: 10.3390/diagnostics12071576.

Perspective: Chicken Models for Studying the Ontogenetic Origin of Neuropsychiatric Disorders.

Huang X, Cheng H Biomedicines. 2022; 10(5).

PMID: 35625892 PMC: 9138209. DOI: 10.3390/biomedicines10051155.

References

Rush A, Gullion C, Basco M, Jarrett R, Trivedi M . The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychol Med. 1996; 26(3):477-86. DOI: 10.1017/s0033291700035558. View

Mulder E, Ververs F, Heus R, H A Visser G . Selective serotonin reuptake inhibitors affect neurobehavioral development in the human fetus. Neuropsychopharmacology. 2011; 36(10):1961-71. PMC: 3158314. DOI: 10.1038/npp.2011.67. View

Trivedi M, Rush A, Ibrahim H, Carmody T, Biggs M, Suppes T . The Inventory of Depressive Symptomatology, Clinician Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a.... Psychol Med. 2004; 34(1):73-82. DOI: 10.1017/s0033291703001107. View

Zeskind P, Stephens L . Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior. Pediatrics. 2004; 113(2):368-75. DOI: 10.1542/peds.113.2.368. View

Sodhi M, Sanders-Bush E . Serotonin and brain development. Int Rev Neurobiol. 2004; 59:111-74. DOI: 10.1016/S0074-7742(04)59006-2. View

Carey K, Cocco K, Simons J . Concurrent validity of clinicians' ratings of substance abuse among psychiatric outpatients. Psychiatr Serv. 1996; 47(8):842-7. DOI: 10.1176/ps.47.8.842. View

Sobell L, Agrawal S, Annis H, Echeverria L, Leo G, Rybakowski J . Cross-cultural evaluation of two drinking assessment instruments: alcohol timeline followback and inventory of drinking situations. Subst Use Misuse. 2001; 36(3):313-31. DOI: 10.1081/ja-100102628. View

Mulak A, Tache Y, Larauche M . Sex hormones in the modulation of irritable bowel syndrome. World J Gastroenterol. 2014; 20(10):2433-48. PMC: 3949254. DOI: 10.3748/wjg.v20.i10.2433. View

Pawlby S, Hay D, Sharp D, Waters C, OKeane V . Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community-based study. J Affect Disord. 2008; 113(3):236-43. DOI: 10.1016/j.jad.2008.05.018. View

10.

Shelton R . The dual-action hypothesis: does pharmacology matter?. J Clin Psychiatry. 2004; 65 Suppl 17:5-10. View

11.

Duhig A, Cavallo D, McKee S, George T, Krishnan-Sarin S . Daily patterns of alcohol, cigarette, and marijuana use in adolescent smokers and nonsmokers. Addict Behav. 2004; 30(2):271-83. DOI: 10.1016/j.addbeh.2004.05.016. View

12.

Moses-Kolko E, Bogen D, Perel J, Bregar A, Uhl K, Levin B . Neonatal signs after late in utero exposure to serotonin reuptake inhibitors: literature review and implications for clinical applications. JAMA. 2005; 293(19):2372-83. DOI: 10.1001/jama.293.19.2372. View

13.

Beck A, Ward C, Mendelson M, Mock J, ERBAUGH J . An inventory for measuring depression. Arch Gen Psychiatry. 1961; 4:561-71. DOI: 10.1001/archpsyc.1961.01710120031004. View

14.

Melville J, Gavin A, Guo Y, Fan M, Katon W . Depressive disorders during pregnancy: prevalence and risk factors in a large urban sample. Obstet Gynecol. 2010; 116(5):1064-70. PMC: 3068619. DOI: 10.1097/AOG.0b013e3181f60b0a. View

15.

Clarke G, Stilling R, Kennedy P, Stanton C, Cryan J, Dinan T . Minireview: Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 2014; 28(8):1221-38. PMC: 5414803. DOI: 10.1210/me.2014-1108. View

16.

Salisbury A, OGrady K, Battle C, Wisner K, Anderson G, Stroud L . The Roles of Maternal Depression, Serotonin Reuptake Inhibitor Treatment, and Concomitant Benzodiazepine Use on Infant Neurobehavioral Functioning Over the First Postnatal Month. Am J Psychiatry. 2015; 173(2):147-57. PMC: 4742381. DOI: 10.1176/appi.ajp.2015.14080989. View

17.

Dinan T, Cryan J . The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterol Clin North Am. 2017; 46(1):77-89. DOI: 10.1016/j.gtc.2016.09.007. View

18.

Rush A, Trivedi M, Ibrahim H, Carmody T, Arnow B, Klein D . The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry. 2003; 54(5):573-83. DOI: 10.1016/s0006-3223(02)01866-8. View

19.

Hendrick V, Stowe Z, Altshuler L, Hwang S, Lee E, Haynes D . Placental passage of antidepressant medications. Am J Psychiatry. 2003; 160(5):993-6. DOI: 10.1176/appi.ajp.160.5.993. View

20.

Levinson-Castiel R, Merlob P, Linder N, Sirota L, Klinger G . Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants. Arch Pediatr Adolesc Med. 2006; 160(2):173-6. DOI: 10.1001/archpedi.160.2.173. View