Mood and Behavior Seasonality in Glaucoma; Assessing Correlations Between Seasonality and Structure and Function of the Retinal Ganglion Cells

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2020 Mar 13

PMID 32163458

Citations 1

Authors

Helle Ostergaard Madsen

Shakoor Ba-Ali

Henrik Lund-Andersen

Klaus Martiny

Ida Hageman

Affiliations

Soon will be listed here.

Abstract

Aim: In glaucoma, depression and disturbed sleep has been associated with degeneration of the intrinsically photosensitive retinal ganglion cells, that mediate non-image forming effects of light such as regulation of circadian rhythm, alertness and mood. In this study we assessed associations between seasonal mood and behavior variation and retinal ganglion cell damage in outpatients with glaucoma.

Methods: The seasonal pattern assessment questionnaire was administered to outpatients with glaucoma. Data on visual field defects identified by autoperimetry and retinal nerve fiber layer thickness visualized by ocular coherence tomography were collected from patient charts. The correlations between seasonality and retinal damage were tested and the adjusted effects of retinal function on seasonality were evaluated in a linear regression model.

Results: In total, 113 persons completed the questionnaire. Of these, 4% fulfilled the criteria for seasonal affective disorder (SAD) and 8% for subsyndromal seasonal affective disorder (sSAD). Mean global seasonal score was 4.3. There were no significant correlations between seasonality and either visual field or retinal nerve fiber layer thickness. In the adjusted analysis there were trends toward differential effects of visual field on seasonality in subgroups with different sex and type of glaucoma.

Conclusion: There were no strong associations between seasonality and visual field or retinal nerve fiber layer thickness. Sex, age and glaucoma subtype may modify light effects on complex regulatory systems.

Citing Articles

The Role of Season, Sunlight, and Light Sensitivity in Self-Reported Depressive Symptoms by Adults With Visual Impairment.

van der Linden R, van der Aa H, van Nispen R Transl Vis Sci Technol. 2024; 13(10):2.

PMID: 39352713 PMC: 11451827. DOI: 10.1167/tvst.13.10.2.

References

LeGates T, Fernandez D, Hattar S . Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci. 2014; 15(7):443-54. PMC: 4254760. DOI: 10.1038/nrn3743. View

Reeves G, Nijjar G, Langenberg P, Johnson M, Khabazghazvini B, Sleemi A . Improvement in depression scores after 1 hour of light therapy treatment in patients with seasonal affective disorder. J Nerv Ment Dis. 2012; 200(1):51-5. PMC: 5336550. DOI: 10.1097/NMD.0b013e31823e56ca. View

Ahmadi H, Lund-Andersen H, Kolko M, Bach-Holm D, Alberti M, Ba-Ali S . Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma. Acta Ophthalmol. 2019; 98(1):65-73. DOI: 10.1111/aos.14133. View

Meesters Y, Winthorst W, Duijzer W, Hommes V . The effects of low-intensity narrow-band blue-light treatment compared to bright white-light treatment in sub-syndromal seasonal affective disorder. BMC Psychiatry. 2016; 16:27. PMC: 4758137. DOI: 10.1186/s12888-016-0729-5. View

Gracitelli C, Duque-Chica G, Moura A, Roizenblatt M, Nagy B, de Melo G . Relationship between Daytime Sleepiness and Intrinsically Photosensitive Retinal Ganglion Cells in Glaucomatous Disease. J Ophthalmol. 2016; 2016:5317371. PMC: 4756205. DOI: 10.1155/2016/5317371. View

Rosenthal N, Sack D, Gillin J, Lewy A, Goodwin F, Davenport Y . Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 1984; 41(1):72-80. DOI: 10.1001/archpsyc.1984.01790120076010. View

Gracitelli C, Duque-Chica G, Moura A, Nagy B, de Melo G, Roizenblatt M . A positive association between intrinsically photosensitive retinal ganglion cells and retinal nerve fiber layer thinning in glaucoma. Invest Ophthalmol Vis Sci. 2014; 55(12):7997-8005. DOI: 10.1167/iovs.14-15146. View

Berman G, Muttuvelu D, Berman D, Larsen J, Licht R, Ledolter J . Decreased retinal sensitivity in depressive disorder: a controlled study. Acta Psychiatr Scand. 2018; 137(3):231-240. DOI: 10.1111/acps.12851. View

Fernandez D, Fogerson P, Lazzerini Ospri L, Thomsen M, Layne R, Severin D . Light Affects Mood and Learning through Distinct Retina-Brain Pathways. Cell. 2018; 175(1):71-84.e18. PMC: 6190605. DOI: 10.1016/j.cell.2018.08.004. View

10.

Ayaki M, Shiba D, Negishi K, Tsubota K . Depressed visual field and mood are associated with sleep disorder in glaucoma patients. Sci Rep. 2016; 6:25699. PMC: 4863426. DOI: 10.1038/srep25699. View

11.

Bierings R, Gordijn M, Jansonius N . Chronotyping glaucoma patients with the Munich ChronoType Questionnaire: A case-control study. PLoS One. 2019; 14(3):e0214046. PMC: 6438473. DOI: 10.1371/journal.pone.0214046. View

12.

Pjrek E, Baldinger-Melich P, Spies M, Papageorgiou K, Kasper S, Winkler D . Epidemiology and socioeconomic impact of seasonal affective disorder in Austria. Eur Psychiatry. 2016; 32:28-33. DOI: 10.1016/j.eurpsy.2015.11.001. View

13.

Zhang X, Olson D, Le P, Lin F, Fleischman D, Davis R . The Association Between Glaucoma, Anxiety, and Depression in a Large Population. Am J Ophthalmol. 2017; 183:37-41. DOI: 10.1016/j.ajo.2017.07.021. View

14.

Gubin D, Malishevskaya T, Astakhov Y, Astakhov S, Cornelissen G, Kuznetsov V . Progressive retinal ganglion cell loss in primary open-angle glaucoma is associated with temperature circadian rhythm phase delay and compromised sleep. Chronobiol Int. 2019; 36(4):564-577. DOI: 10.1080/07420528.2019.1566741. View

15.

Obara E, Hannibal J, Heegaard S, Fahrenkrug J . Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients. Invest Ophthalmol Vis Sci. 2016; 57(11):4661-7. DOI: 10.1167/iovs.16-19997. View

16.

Lavoie M, Lam R, Bouchard G, Sasseville A, Charron M, Gagne A . Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder. Biol Psychiatry. 2009; 66(3):253-8. DOI: 10.1016/j.biopsych.2008.11.020. View

17.

LeGates T, Altimus C, Wang H, Lee H, Yang S, Zhao H . Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature. 2012; 491(7425):594-8. PMC: 3549331. DOI: 10.1038/nature11673. View

18.

Chen Y, Lai Y, Wang J, Shen Y, Wang C, Chen H . The association between glaucoma and risk of depression: a nationwide population-based cohort study. BMC Ophthalmol. 2018; 18(1):146. PMC: 6013853. DOI: 10.1186/s12886-018-0811-5. View

19.

Adhikari P, Zele A, Thomas R, Feigl B . Quadrant Field Pupillometry Detects Melanopsin Dysfunction in Glaucoma Suspects and Early Glaucoma. Sci Rep. 2016; 6:33373. PMC: 5020729. DOI: 10.1038/srep33373. View

20.

Lanzani M, de Zavalia N, Fontana H, Sarmiento M, Golombek D, Rosenstein R . Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma. Chronobiol Int. 2012; 29(7):911-9. DOI: 10.3109/07420528.2012.691146. View