Association of Obesity and Anovulatory Infertility

Overview

Journal Einstein (Sao Paulo)

Specialty General Medicine

Date 2020 Mar 12

PMID 32159605

Citations 7

Authors

Valeria Fichman

Roseli de Souza Santos da Costa

Teresa Cristina Miglioli

Lizanka Paola Figueiredo Marinheiro

Affiliations

Soon will be listed here.

Abstract

Objective: To verify the association of obesity and infertility related to anovulatory issues.

Methods: This case-control study was carried out with 52 women, aged 20 to 38 years, divided into two groups (infertile - cases - and fertile - control), seen at outpatient clinics, in the period from April to December, 2017.

Results: We found significant evidence that obesity negatively affects women's fertility (p=0.017). The group of infertile women was 7.5-fold more likely to be obese than fertile women.

Conclusion: Strategies that encourage weight control are indicated for women with chronic anovulation, due to hight metabolic activity of adipose tissue.

Citing Articles

Diet-induced obesity alters the ovarian chemical biotransformation and oxidative stress response proteins both basally and in response to 7,12-dimethylbenz[a]anthracene exposure.

Timme K, Inyang I, White H, Keating A Toxicol Sci. 2025; 204(1):9-19.

PMID: 39910959 PMC: 11879017. DOI: 10.1093/toxsci/kfae150.

Attenuation of palmitic acid-induced lysyl oxidase overexpression in the ovary contributes to the improvement of ovulation in obesity by metformin.

Zhang C, Wang W, Yao G, Zhu Y, Lin Y, Lu J Hum Reprod Open. 2024; 2024(1):hoae002.

PMID: 38333108 PMC: 10850847. DOI: 10.1093/hropen/hoae002.

Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome.

Furtado C, Hansen M, Kogure G, Ribeiro V, Taylor N, Soares M Epigenetics. 2024; 19(1):2305082.

PMID: 38245873 PMC: 10802204. DOI: 10.1080/15592294.2024.2305082.

Pathophysiology of obesity-related infertility and its prevention and treatment by potential phytotherapeutics.

Uddandrao V, Brahma Naidu P, Chandrasekaran P, Saravanan G Int J Obes (Lond). 2023; 48(2):147-165.

PMID: 37963998 DOI: 10.1038/s41366-023-01411-4.

Impact of Physical Activity and Sedentary Behavior on Spontaneous Female and Male Fertility: A Systematic Review.

Brinson A, da Silva S, Hesketh K, Evenson K J Phys Act Health. 2023; 20(7):600-615.

PMID: 37146984 PMC: 7614776. DOI: 10.1123/jpah.2022-0487.

References

Lear S, James P, Ko G, Kumanyika S . Appropriateness of waist circumference and waist-to-hip ratio cutoffs for different ethnic groups. Eur J Clin Nutr. 2009; 64(1):42-61. DOI: 10.1038/ejcn.2009.70. View

Lim S, Norman R, Davies M, Moran L . The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis. Obes Rev. 2012; 14(2):95-109. DOI: 10.1111/j.1467-789X.2012.01053.x. View

Campanho C, Heinrich J, Couto E, Barini R . [Subfertility phenotype, chromosome polymorphism and conception failures]. Rev Bras Ginecol Obstet. 2011; 33(5):246-51. View

Bastard J, Maachi M, Lagathu C, Kim M, Caron M, Vidal H . Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006; 17(1):4-12. View

Pandey S, Pandey S, Maheshwari A, Bhattacharya S . The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci. 2011; 3(2):62-7. PMC: 2970793. DOI: 10.4103/0974-1208.69332. View

Hammond R, Levine R . The economic impact of obesity in the United States. Diabetes Metab Syndr Obes. 2011; 3:285-95. PMC: 3047996. DOI: 10.2147/DMSOTT.S7384. View

Diamanti-Kandarakis E . Role of obesity and adiposity in polycystic ovary syndrome. Int J Obes (Lond). 2007; 31 Suppl 2:S8-13. DOI: 10.1038/sj.ijo.0803730. View

Grodstein F, Goldman M, Cramer D . Body mass index and ovulatory infertility. Epidemiology. 1994; 5(2):247-50. DOI: 10.1097/00001648-199403000-00016. View

Jarrett B, Lujan M . Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS. Reproduction. 2016; . PMC: 5411334. DOI: 10.1530/REP-16-0385. View

10.

Talmor A, Dunphy B . Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015; 29(4):498-506. DOI: 10.1016/j.bpobgyn.2014.10.014. View

11.

Simoes Gaspar R, Benevides R, Fontelles J, Vale C, Franca L, Barros P . Reproductive alterations in hyperinsulinemic but normoandrogenic MSG obese female rats. J Endocrinol. 2016; 229(2):61-72. DOI: 10.1530/JOE-15-0453. View

12.

Weiss R, Clapauch R . Female infertility of endocrine origin. Arq Bras Endocrinol Metabol. 2014; 58(2):144-52. DOI: 10.1590/0004-2730000003021. View

13.

. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012; 99(1):63. DOI: 10.1016/j.fertnstert.2012.09.023. View

14.

Reyes-Munoz E, Ortega-Gonzalez C, Martinez-Cruz N, Arce-Sanchez L, Estrada-Gutierrez G, Moran C . Association of obesity and overweight with the prevalence of insulin resistance, pre-diabetes and clinical-biochemical characteristics among infertile Mexican women with polycystic ovary syndrome: a cross-sectional study. BMJ Open. 2016; 6(7):e012107. PMC: 4964199. DOI: 10.1136/bmjopen-2016-012107. View

15.

. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2002; 26 Suppl 1:S5-20. DOI: 10.2337/diacare.26.2007.s5. View

16.

Ramlau-Hansen C, Thulstrup A, Nohr E, Bonde J, Sorensen T, Olsen J . Subfecundity in overweight and obese couples. Hum Reprod. 2007; 22(6):1634-7. DOI: 10.1093/humrep/dem035. View

17.

Milone M, De Placido G, Musella M, Sosa Fernandez L, Sosa Fernandez L, Campana G . Incidence of Successful Pregnancy After Weight Loss Interventions in Infertile Women: a Systematic Review and Meta-Analysis of the Literature. Obes Surg. 2015; 26(2):443-51. DOI: 10.1007/s11695-015-1998-7. View

18.

Mariath A, Grillo L, Silva R, Schmitz P, Campos I, Medina J . [Obesity and risk factors for the development of chronic non-transmissible diseases among consumers in a foodservice unit]. Cad Saude Publica. 2007; 23(4):897-905. DOI: 10.1590/s0102-311x2007000400017. View

19.

Ehrmann D . Polycystic ovary syndrome. N Engl J Med. 2005; 352(12):1223-36. DOI: 10.1056/NEJMra041536. View

20.

Nasiri N, Moini A, Eftekhari-Yazdi P, Karimian L, Salman-Yazdi R, Zolfaghari Z . Abdominal obesity can induce both systemic and follicular fluid oxidative stress independent from polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2014; 184:112-6. DOI: 10.1016/j.ejogrb.2014.11.008. View