Effects of Cisapride on the Pancreatic Exocrine Secretion in Rats

Overview

Journal Gastroenterol Jpn

Specialty Gastroenterology

Date 1988 Oct 1

PMID 3215439

Authors

A Funakoshi

K Miyasaka

H Shinozaki

K Kitani

Affiliations

Soon will be listed here.

Abstract

Exocrine pancreatic secretion to intravenous injections of a new stimulant of gastrointestinal motility, R51,619 (cisapride) was studied in conscious rats, and in the isolated pancreatic acini in vitro. The injection of cisapride (2 mg/kg) significantly increased fluid, bicarbonate and protein output in vivo. Atropine completely abolished the pancreatic responses to cisapride, and CR 1409, a new glutaramic acid derivative and a competitive cholecystokinin (CCK) inhibitor, tended to decrease the cisapride-induced pancreatic exocrine secretion. However, amylase release and Ca2+ efflux from the isolated pancreatic acini were not stimulated. These results suggest that cisapride indirectly affects the pancreatic exocrine secretion primarily by releasing acethycholine from the intrapancreatic nerve endings and in part by releasing CCK from the duodenum, but has no direct action on the pancreas.

References

Miyasaka K, Green G . Effect of partial exclusion of pancreatic juice on rat basal pancreatic secretion. Gastroenterology. 1984; 86(1):114-9. View

Shinozaki H, Kimura T, Imamura K, IBAYASHI H . Participation of Ca2+ and calmodulin in rat pancreatic enzyme secretion induced by secretin, forskolin, and dibutyryl cyclic AMP. Jpn J Physiol. 1986; 36(6):1079-92. DOI: 10.2170/jjphysiol.36.1079. View

Miyasaka K, Kitani K, Green G . The sequential changes in pancreatic exocrine function after abdominal surgery in the rat. Pancreas. 1986; 1(4):347-53. DOI: 10.1097/00006676-198607000-00010. View

McCallum R . Review of the current status of prokinetic agents in gastroenterology. Am J Gastroenterol. 1985; 80(12):1008-16. View

Petersen H, GROSSMAN M . Pancreatic exocrine secretion in anesthetized and conscious rats. Am J Physiol. 1977; 233(6):E530-6. DOI: 10.1152/ajpendo.1977.233.6.E530. View

Bruzzone R, Pozzan T, Wollheim C . Caerulein and carbamoylcholine stimulate pancreatic amylase release at resting cytosolic free Ca2+. Biochem J. 1986; 235(1):139-43. PMC: 1146660. DOI: 10.1042/bj2350139. View

Makovec F, Chiste R, Bani M, Pacini M, Setnikar I, ROVATI L . New glutaramic acid derivatives with potent competitive and specific cholecystokinin-antagonistic activity. Arzneimittelforschung. 1985; 35(7):1048-51. View

Imamura K, Wakasugi H, Shinozaki H, IBAYASHI H . Dynamic analysis of secretagogue-induced amylase secretion from rat pancreatic acini studied by perifusion system. Jpn J Physiol. 1983; 33(5):687-98. DOI: 10.2170/jjphysiol.33.687. View

Koop H, Monnikes H, Koop I, Dionysius J, Schwarz C, Arnold R . Effect of the prokinetic drug cisapride on gastrointestinal hormone release. Scand J Gastroenterol. 1986; 21(8):907-13. DOI: 10.3109/00365528608996394. View

10.

Miyasaka K, Nakamura R, Funakoshi A, Kitani K . Inhibitory effect of CR-1409, a competitive inhibitor of cholecystokinin, on pancreatic exocrine secretion in the conscious rat. Tohoku J Exp Med. 1988; 155(2):165-72. DOI: 10.1620/tjem.155.165. View

11.

Gardner J . Regulation of pancreatic exocrine function in vitro: initial steps in the actions of secretagogues. Annu Rev Physiol. 1979; 41:55-66. DOI: 10.1146/annurev.ph.41.030179.000415. View

12.

Funakoshi A, Shinozaki H, Miyazaki K, Nakano I, IBAYASHI H . Effects of cisapride on the secretion of pancreatic polypeptide in healthy volunteers. Tohoku J Exp Med. 1986; 150(2):155-60. DOI: 10.1620/tjem.150.155. View