Single Molecule Sensing of Amyloid-β Aggregation by Confined Glass Nanopores

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2020 Mar 11

PMID 32153747

Citations 18

Authors

Ru-Jia Yu

Si-Min Lu

Su-Wen Xu

Yuan-Jie Li

Qun Xu

Yi-Lun Ying

Yi-Tao Long

Affiliations

Soon will be listed here.

Abstract

We have developed a glass nanopore based single molecule tool to investigate the dynamic oligomerization and aggregation process of Aβ1-42 peptides. The intrinsic differences in the molecular size and surface charge of amyloid aggregated states could be distinguished through single molecule induced characteristic current fluctuation. More importantly, our results reveal that the neurotoxic Aβ1-42 oligomer tends to adsorb onto the solid surface of nanopores, which may explain its instability and highly neurotoxic features.

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