The Biological Mechanism Involved in Anticancer Properties of Amniotic Membrane

Overview

Journal Oncol Rev

Specialty Oncology

Date 2020 Mar 11

PMID 32153725

Citations 3

Authors

Ameneh Jafari

Hassan Niknejad

Mostafa Rezaei-Tavirani

Hakimeh Zali

Affiliations

Soon will be listed here.

Abstract

The main role of amniotic membrane (AM), or amnion, is to protect the fetus from drying out and create an appropriate environment for its growth. AM is also a suitable candidate for the treatment of various diseases due to its unique characteristics. In recent years, a new line of research has focused on the anticancer properties of amnion and its potential use in cancer treatment. The and studies indicate the anti-proliferative and proapoptotic activities, as well as the angioregulatory and immunomodulatory properties of the amniotic membrane. However, the exact mechanism and molecular basis of these anticancer effects of AM are not fully elucidated. This paper presents an overview of the latest findings and knowledge about the anticancer effects of AM and its underlying molecular mechanisms, which is crucial for the application of amnion in cancer therapy.

Citing Articles

Application of the Human Amniotic Membrane as an Adjuvant Therapy for the Treatment of Hepatocellular Carcinoma.

Abou-Shanab A, Gaser O, Salah R, El-Badri N Adv Exp Med Biol. 2023; 1470:129-146.

PMID: 38036871 DOI: 10.1007/5584_2023_792.

Lyophilised Amniotic Membrane in Intraoral Surgical Defects: A Prospective Clinical Study.

Hazarika K, Malik K, Adhyapok A, Debnath S Ann Maxillofac Surg. 2022; 12(1):5-10.

PMID: 36199459 PMC: 9527846. DOI: 10.4103/ams.ams_152_21.

A Review on Modifications of Amniotic Membrane for Biomedical Applications.

Dadkhah Tehrani F, Firouzeh A, Shabani I, Shabani A Front Bioeng Biotechnol. 2021; 8:606982.

PMID: 33520961 PMC: 7839407. DOI: 10.3389/fbioe.2020.606982.

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