Recent Advances in Understanding Resistance Exercise Training-induced Skeletal Muscle Hypertrophy in Humans

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2020 Mar 10

PMID 32148775

Citations 25

Authors

Sophie Joanisse

Changhyun Lim

James McKendry

Jonathan C Mcleod

Tanner Stokes

Stuart M Phillips

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is foundational to the process of functional hypertrophy. Much of our current understanding of skeletal muscle hypertrophy can be attributed to the development and utilization of stable isotopically labeled tracers. We know that resistance exercise and sufficient protein intake act synergistically and provide the most effective stimuli to enhance skeletal muscle mass; however, the molecular intricacies that underpin the tremendous response variability to resistance exercise-induced hypertrophy are complex. The purpose of this review is to discuss recent studies with the aim of shedding light on key regulatory mechanisms that dictate hypertrophic gains in skeletal muscle mass. We also aim to provide a brief up-to-date summary of the recent advances in our understanding of skeletal muscle hypertrophy in response to resistance training in humans.

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