Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature

Overview

Journal Case Rep Med

Publisher Wiley

Specialty General Medicine

Date 2020 Mar 10

PMID 32148514

Citations 5

Authors

Amna Ahmed

Alejandro Granillo

Ethan Burns

Kerri Glassner

Nishath Naseem

Christopher Force

Suzanne M Crumley

Ashley Drews

Affiliations

Soon will be listed here.

Abstract

Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. Despite early clinical deterioration, prompt initiation of therapy with intravenous acyclovir and methylprednisolone led to rapid improvement.

Citing Articles

Herpes Simplex Virus Type 2 Hepatitis: An Uncommon Cause of Persistent Fever in a Late Post-Transplant Liver Recipient.

Gavrancic T, Stoddard K, Lewis J, Gorasevic M, Murawska Baptista A, Cortes M Am J Case Rep. 2024; 25:e945140.

PMID: 39618065 PMC: 11622330. DOI: 10.12659/AJCR.945140.

Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment.

Hrynkiewicz R, Niedzwiedzka-Rystwej P Front Immunol. 2023; 14:1153528.

PMID: 37153560 PMC: 10160486. DOI: 10.3389/fimmu.2023.1153528.

Fulminating herpes simplex hepatitis.

Ahmed R, Green K, Litovsky S, Al Diffalha S Autops Case Rep. 2022; 12:e2021410.

PMID: 36569985 PMC: 9762517. DOI: 10.4322/acr.2021.410.

A Surprising Cause of Liver Abscesses in a Post-Chemotherapy Patient: Herpes Simplex Virus.

Ehwarieme R, Agarwal A, Alkhateb R, Bowling J, Anstead G Cureus. 2021; 13(9):e17744.

PMID: 34659957 PMC: 8491800. DOI: 10.7759/cureus.17744.

Acute liver failure due to herpes simplex virus: diagnostic clues and potential role of plasmapheresis: A case report.

Chavez S, Poniachik J, Urzua A, Roblero J, Cattaneo M, Jimenez A Medicine (Baltimore). 2021; 100(35):e27139.

PMID: 34477166 PMC: 8416005. DOI: 10.1097/MD.0000000000027139.

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