Refining Rodent Models of Spinal Cord Injury

Overview

Journal Exp Neurol

Specialty Neurology

Date 2020 Mar 7

PMID 32142803

Citations 30

Authors

Elliot Lilley

Melissa R Andrews

Elizabeth J Bradbury

Heather Elliott

Penny Hawkins

Ronaldo M Ichiyama

Jo Keeley

Adina T Michael-Titus

Lawrence D F Moon

Stefano Pluchino

John Riddell

Kathy Ryder

Ping K Yip

Affiliations

Soon will be listed here.

Abstract

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

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