Immunoglobulin E Antibody Levels in Patients with Asthma Compared with Non-asthma

Overview

Journal Heliyon

Specialty Social Sciences

Date 2020 Mar 7

PMID 32140608

Citations 4

Authors

Tamar A Smith-Norowitz

Jeffrey Loeffler

Yvonne Huang

Elliot Klein

Yitzchok M Norowitz

Margaret R Hammerschlag

Rauno Joks

Stephan Kohlhoff

Affiliations

Soon will be listed here.

Abstract

is an obligate intracellular bacterium that causes respiratory infection in adults and children. There is evidence for an association between atypical bacterial pathogens and asthma pathogenesis. We sought to determine whether past infection triggers - IgE antibodies (Abs) in asthmatics and non-asthmatics, who had detectable IgG titers. IgE Abs were quantified using enzyme immunoassay (EIA). IgE Ab levels were higher in asthmatics compared with non-asthmatics. There was no correlation found between total serum IgE levels and specific IgE Ab levels. infection may trigger IgE-specific responses in asthmatics.

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References

Smith-Norowitz T, Silverberg J, Kusonruksa M, Weaver D, Ginsburg D, Norowitz K . Asthmatic children have increased specific anti-Mycoplasma pneumoniae IgM but not IgG or IgE-values independent of history of respiratory tract infection. Pediatr Infect Dis J. 2013; 32(6):599-603. DOI: 10.1097/INF.0b013e3182862ea8. View

Rath N, Raje N, Rosenwasser L . Immunoglobulin E as a Biomarker in Asthma. Immunol Allergy Clin North Am. 2018; 38(4):587-597. DOI: 10.1016/j.iac.2018.06.007. View

Froidure A, Mouthuy J, Durham S, Chanez P, Sibille Y, Pilette C . Asthma phenotypes and IgE responses. Eur Respir J. 2015; 47(1):304-19. DOI: 10.1183/13993003.01824-2014. View

Kutlin A, Roblin P, Hammerschlag M . Antibody response to Chlamydia pneumoniae infection in children with respiratory illness. J Infect Dis. 1998; 177(3):720-4. DOI: 10.1086/514223. View

Tanaka A, Jinno M, Hirai K, Miyata Y, Mizuma H, Yamaguchi M . Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control. Respir Res. 2014; 15:144. PMC: 4245732. DOI: 10.1186/s12931-014-0144-8. View

Sandeep T, Roopakala M, Silvia C, Chandrashekara S, Rao M . Evaluation of serum immunoglobulin E levels in bronchial asthma. Lung India. 2010; 27(3):138-40. PMC: 2946714. DOI: 10.4103/0970-2113.68312. View

Lux H, Lenz K, Budnik L, Baur X . Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis. Occup Environ Med. 2019; 76(4):269-278. DOI: 10.1136/oemed-2018-105434. View

Johnston S, Martin R . Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis?. Am J Respir Crit Care Med. 2005; 172(9):1078-89. DOI: 10.1164/rccm.200412-1743PP. View

Patel K, Anderson E, Salva P, Webley W . The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms. Respir Res. 2012; 13:32. PMC: 3441249. DOI: 10.1186/1465-9921-13-32. View

10.

Hahn D, Schure A, Patel K, Childs T, Drizik E, Webley W . Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. PLoS One. 2012; 7(4):e35945. PMC: 3335830. DOI: 10.1371/journal.pone.0035945. View

11.

Martin R, Kraft M, Chu H, Berns E, Cassell G . A link between chronic asthma and chronic infection. J Allergy Clin Immunol. 2001; 107(4):595-601. DOI: 10.1067/mai.2001.113563. View

12.

Poddighe D, Comi E, Brambilla I, Licari A, Bruni P, Marseglia G . Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases. Iran J Allergy Asthma Immunol. 2018; 17(5):490-496. View

13.

Reddel H, Levy M . The GINA asthma strategy report: what's new for primary care?. NPJ Prim Care Respir Med. 2015; 25:15050. PMC: 4519996. DOI: 10.1038/npjpcrm.2015.50. View

14.

Hammerschlag M, Chirgwin K, Roblin P, Gelling M, DuMornay W, MANDEL L . Persistent infection with Chlamydia pneumoniae following acute respiratory illness. Clin Infect Dis. 1992; 14(1):178-82. DOI: 10.1093/clinids/14.1.178. View

15.

Asher M, Montefort S, Bjorksten B, Lai C, Strachan D, Weiland S . Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006; 368(9537):733-43. DOI: 10.1016/S0140-6736(06)69283-0. View

16.

Emre U, Sokolovskaya N, Roblin P, Schachter J, Hammerschlag M . Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease. J Infect Dis. 1995; 172(1):265-7. DOI: 10.1093/infdis/172.1.265. View

17.

BARBEE R, Halonen M, Kaltenborn W, Lebowitz M, Burrows B . A longitudinal study of serum IgE in a community cohort: correlations with age, sex, smoking, and atopic status. J Allergy Clin Immunol. 1987; 79(6):919-27. DOI: 10.1016/0091-6749(87)90241-7. View