The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 Mar 7

PMID 32140159

Citations 27

Authors

Jinbo Cheng

Shukun Wang

Yuan Dong

Zengqiang Yuan

Affiliations

Soon will be listed here.

Abstract

The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration. Recently, mounting evidence has suggested that Hippo signaling also has an important role in regulating immunity, including innate and adaptive immune activation. In the neuronal system, Our laboratory results, together with those from other studies, demonstrate that the Hippo signaling pathway is involved in neuroinflammation, neuronal cell differentiation, and neuronal death. In the present review, we summarize the recent findings pertaining to the function and regulatory mechanism of Hippo signaling components in the neuronal system, implicating the potential of Hippo signaling as a therapeutic target for the treatment of neuronal system diseases.

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