Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8 T Cell Receptors

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 Mar 7

PMID 32140156

Citations 5

Authors

Louise C Rowntree

Heleen van den Heuvel

Jessica Sun

Lloyd J DOrsogna

Thi H O Nguyen

Frans H J Claas

Jamie Rossjohn

Tom C Kotsimbos

Anthony W Purcell

Nicole A Mifsud

Affiliations

Soon will be listed here.

Abstract

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8 T cells directed against peptides derived from chronic viruses (EBV, CMV, and HIV-1) presented by high frequency HLA-A and -B allomorphs differentially cross-react toward HLA-B27 allotypes in a highly focused and hierarchical manner. Given the commonality of cross-reactive T cells and their potential contribution to adverse outcomes in allogeneic transplants, our study demonstrates that multiple antiviral T cells recognizing the same HLA allomorph could pose an extra layer of complexity for organ matching.

Citing Articles

Development and validation of a machine learning-based nomogram for predicting HLA-B27 expression.

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