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TSPAN8 As a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy

Overview
Journal Biomolecules
Publisher MDPI
Date 2020 Mar 7
PMID 32138170
Citations 20
Authors
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Abstract

Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-mediated protein complexes by interacting with themselves and other various cellular signaling molecules. These protein complexes help build tetraspanin-enriched microdomains (TEMs) that efficiently mediate intracellular signal transduction. In physiological conditions, TSPAN8 plays a vital role in the regulation of biological functions, including leukocyte trafficking, angiogenesis and wound repair. Recently, reports have increasingly shown the functional role and clinical relevance of TSPAN8 overexpression in the progression and metastasis of several cancers. In this review, we will highlight the physiological and pathophysiological roles of TSPAN8 in normal and cancer cells. Additionally, we will cover the current status of monoclonal antibodies specifically targeting TSPAN8 and the importance of TSPAN8 as an emerging therapeutic target in cancers for monoclonal antibody therapy.

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References
1.
Pan S, Wu Y, Cai S, Pan Y, Liu W, Bian L . Over-expression of tetraspanin 8 in malignant glioma regulates tumor cell progression. Biochem Biophys Res Commun. 2015; 458(3):476-482. DOI: 10.1016/j.bbrc.2015.01.128. View

2.
Jiang H, Liu W, Zhan S, Pan Y, Bian L, Sun B . GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings. PLoS One. 2016; 11(8):e0161017. PMC: 4988667. DOI: 10.1371/journal.pone.0161017. View

3.
Park S, Choi J, Oh E, Kim Y, Park Y, Cho E . Clinical significance of CD151 overexpression in subtypes of invasive breast cancer. Br J Cancer. 2012; 106(5):923-30. PMC: 3306846. DOI: 10.1038/bjc.2012.11. View

4.
Paiva B, Gutierrez N, Chen X, Vidriales M, Montalban M, Rosinol L . Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients. Leukemia. 2012; 26(8):1862-9. DOI: 10.1038/leu.2012.42. View

5.
Green D, Press O . Whither Radioimmunotherapy: To Be or Not To Be?. Cancer Res. 2017; 77(9):2191-2196. PMC: 5413412. DOI: 10.1158/0008-5472.CAN-16-2523. View