Congenital Cytomegalovirus Infection

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2020 Mar 6

PMID 32134480

Citations 21

Authors

Nazia Kabani

Shannon A Ross

Affiliations

Soon will be listed here.

Abstract

Congenital cytomegalovirus (cCMV) infection is a leading cause of hearing loss and neurological disabilities in children, with the disease burden and disabilities due to cCMV greater than many other well recognized childhood conditions. A minority of infants with cCMV will have symptoms at birth. Infants with symptomatic cCMV are at higher risk for sequelae than those born without symptoms. The majority of infants with cCMV are asymptomatic at birth, but 10%-15% will develop hearing loss. Although clinical symptoms can help predict which infants will have sensorineural hearing loss, among asymptomatic cCMV there are currently no predictors of adverse outcome. The identification of a biomarker to identify those at highest risk of sequelae is highly desirable to target interventions to those who could potentially benefit. Because there is increasing rationale for establishing both targeted and universal screening programs for cCMV in the United States and worldwide, this is an urgent priority.

Citing Articles

Predictive Factors for Hearing Loss in Congenital Cytomegalovirus Infection.

Corazzi V, Musumano L, Migliorelli A, Negossi L, Bianchini C, Stomeo F Audiol Res. 2025; 15(1.

PMID: 39846555 PMC: 11755536. DOI: 10.3390/audiolres15010002.

Diagnosis of Congenital Cytomegalovirus in a 14-Month-Old Patient Presenting with Sensorineural Hearing Loss: Storing Dry Blood Samples.

Gok A, Cirdi G, Gunes A, Orgun L, Sayan M, Kara B Turk Arch Pediatr. 2025; 60(1):106-107.

PMID: 39804161 PMC: 11736865. DOI: 10.5152/TurkArchPediatr.2025.2498.

Economic evaluation of newborn screening for congenital cytomegalovirus infection: A systematic review.

Saito H, Sakai K, Tanaka M, Konomura K, Suzuki M, Tajima G Eur J Pediatr. 2025; 184(1):123.

PMID: 39779497 PMC: 11711639. DOI: 10.1007/s00431-024-05953-1.

Maternal Cytomegalovirus (CMV) Serology: The Diagnostic Limitations of CMV IgM and IgG Avidity in Detecting Congenital CMV Infection.

Chan E, Suchet I, Somerset D, de Koning L, Chadha R, Soliman N Pediatr Dev Pathol. 2024; 27(6):530-544.

PMID: 39270128 PMC: 11568646. DOI: 10.1177/10935266241253477.

Awareness and Knowledge of Congenital Cytomegalovirus (cCMV) Among Audiologists and Speech-Language Pathologists in Saudi Arabia: A Cross Sectional Survey.

Aldawood E, Aldawood Z, Alfhili M J Multidiscip Healthc. 2024; 17:4155-4163.

PMID: 39220329 PMC: 11366255. DOI: 10.2147/JMDH.S474581.

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