Mesenchymal Stem Cells Beyond Regenerative Medicine

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Mar 6

PMID 32133358

Citations 40

Authors

Riam Shammaa

Abed El-Hakim El-Kadiry

Jamilah Abusarah

Moutih Rafei

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) are competent suitors of cellular therapy due to their therapeutic impact on tissue degeneration and immune-based pathologies. Additionally, their homing and immunomodulatory properties can be exploited in cancer malignancies to transport pharmacological entities, produce anti-neoplastic agents, or induce anti-tumor immunity. Herein, we create a portfolio for MSC properties, showcasing their distinct multiple therapeutic utilities and successes/challenges thereof in both animal studies and clinical trials. We further highlight the promising potential of MSCs not only in cancer management but also in instigating tumor-specific immunity - i.e., cancer vaccination. Finally, we reflect on the possible reasons impeding the clinical advancement of MSC-based cancer vaccines to assist in contriving novel methodologies from which a therapeutic milestone might emanate.

Citing Articles

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Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary Results.

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