Nanoparticle-Mediated Therapeutic Application for Modulation of Lysosomal Ion Channels and Functions

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2020 Mar 6

PMID 32131531

Citations 5

Authors

Dongun Lee

Jeong Hee Hong

Affiliations

Soon will be listed here.

Abstract

Applications of nanoparticles in various fields have been addressed. Nanomaterials serve as carriers for transporting conventional drugs or proteins through lysosomes to various cellular targets. The basic function of lysosomes is to trigger degradation of proteins and lipids. Understanding of lysosomal functions is essential for enhancing the efficacy of nanoparticles-mediated therapy and reducing the malfunctions of cellular metabolism. The lysosomal function is modulated by the movement of ions through various ion channels. Thus, in this review, we have focused on the recruited ion channels for lysosomal function, to understand the lysosomal modulation through the nanoparticles and its applications. In the future, lysosomal channels-based targets will expand the therapeutic application of nanoparticles-associated drugs.

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