Carcinoma Ex Pleomorphic Adenoma: a Case Report and Review of Literature

Overview

Journal Afr Health Sci

Date 2020 Mar 5

PMID 32127904

Citations 11

Authors

Deepak Khanna

Tanay Chaubal

Ranjeet Bapat

Anshad Mohamed Abdulla

Sunil Thomas Philip

Suraj Arora

Affiliations

Soon will be listed here.

Abstract

Background: Carcinoma ex pleomorphic adenoma (CA-ex-PA) is extremely unusual in minor salivary glands of oral cavity. CAex-PA is a carcinomatous change as a primary or as a recurrence of pleomorphic adenoma.

Objective: Due to resemblance of clinical symptoms of Ca ex PA and benign pleomorphic adenoma, it is mandatory for surgeons to keep high degree of clinical alertness, considering the peculiarity of this tumor.

Case Report: 54-year-old male presented with swelling on left side in the pre-auricular region from the middle of zygomatic arch to mastoid process and from tragus of the ear up to angle of mandible. Fine needle aspiration cytology revealed a mixture of benign and malignant components. Total left parotidectomy with left radical neck dissection followed by reconstruction with cervicodeltopectoral flap was performed. Combination of chemotherapy and radiotherapy were given to patient. Histologic examination and pre-operative fine needle aspiration cytology confirmed the diagnosis of Carcinoma ex pleomorphic adenoma (CA-ex-PA). Two-year follow-up of patient showed no recurrence of the lesion.

Conclusion: Due to the similarity in the clinical symptoms of CA-ex-PA and benign pleomorphic adenoma, it is vital that clinicians maintain a high degree of clinical vigilance, considering the oddity of this malignancy.

Citing Articles

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FGFR2 point mutation in 2 cases of pleomorphic adenoma progressing to myoepithelial carcinoma.

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The Usefulness of Fine Needle Aspiration Cytology in the Management of Parotid Gland Masses at a Tertiary Academic Hospital.

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Influence of p16 Protein Immunostaining on Histopathological Features of Pleomorphic Adenoma and Carcinoma ex- Pleomorphic Adenoma.

Magalhaes I, Barbosa K, Costa G, de Oliveira Filho O, Erialdo da Silva Junior J, Gonzaga Silva L Asian Pac J Cancer Prev. 2023; 24(11):3815-3824.

PMID: 38019239 PMC: 10772772. DOI: 10.31557/APJCP.2023.24.11.3815.

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