Impact of Aerobic Exercise Versus Resisted Exercise on Endothelial Activation Markers and Inflammatory Cytokines Among Elderly

Overview

Journal Afr Health Sci

Date 2020 Mar 5

PMID 32127863

Citations 13

Authors

Shehab M Abd El-Kader

Fadwa M Al-Shreef

Osama H Al-Jiffri

Affiliations

Soon will be listed here.

Abstract

Background: Aging is the major risk factor for the development of cardiovascular diseases as aging increases plasma levels of pro-inflammatory mediators and endothelial dysfunction. Physical exercise is a potential strategy for improving the endothelial dysfunction and chronic inflammation that accompanies aging. However, there is a need to differentiate between aerobic and resistance exercise training regarding endothelial activation markers and systemic inflammation among elderly population.

Objective: The aim of this study was to compare the impact of six months of aerobic versus resisted exercise training on inflammatory cytokines and endothelial activation markers among elderly.

Material And Methods: Eighty previously sedentary elderly subjects participated in this study, their age ranged from 61-66 years. All subjects were randomly assigned to supervised aerobic exercise intervention group (group A, n=40) or resistance exercise group (group B, n=40).

Results: The mean value of interleukin-10 (IL-10) was significantly increased, where the mean value of inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), E-selectin, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) were significantly decreased in group (A) and group (B). In addition, there were significant differences in the mean levels of the investigated parameters between group (A) and group (B) at the end of the study.

Conclusion: The current study provides evidence that aerobic exercise is more appropriate in modulate entering altered endothelial activation and inflammatory markers than resisted exercise among elderly population.

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References

Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, Shah T . Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ. 2011; 342:d548. PMC: 3039696. DOI: 10.1136/bmj.d548. View

Bruunsgaard H, Skinhoj P, Pedersen A, Schroll M, Pedersen B . Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis. Clin Exp Immunol. 2000; 121(2):255-60. PMC: 1905691. DOI: 10.1046/j.1365-2249.2000.01281.x. View

Geffken D, Cushman M, Burke G, Polak J, Sakkinen P, Tracy R . Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol. 2001; 153(3):242-50. DOI: 10.1093/aje/153.3.242. View

Nicklas B, Hsu F, Brinkley T, Church T, Goodpaster B, Kritchevsky S . Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008; 56(11):2045-52. PMC: 2683336. DOI: 10.1111/j.1532-5415.2008.01994.x. View

Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F . Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation. 2000; 101(25):2896-901. DOI: 10.1161/01.cir.101.25.2896. View

Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P . Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis. 2009; 20(8):608-17. DOI: 10.1016/j.numecd.2009.04.015. View

Sugiyama T, Healy G, Dunstan D, Salmon J, Owen N . Joint associations of multiple leisure-time sedentary behaviours and physical activity with obesity in Australian adults. Int J Behav Nutr Phys Act. 2008; 5:35. PMC: 2459202. DOI: 10.1186/1479-5868-5-35. View

Donges C, Duffield R, Drinkwater E . Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Med Sci Sports Exerc. 2010; 42(2):304-13. DOI: 10.1249/MSS.0b013e3181b117ca. View

Devaux B, Scholz D, Hirche A, Klovekorn W, Schaper J . Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J. 1997; 18(3):470-9. DOI: 10.1093/oxfordjournals.eurheartj.a015268. View

10.

Ploeger H, Takken T, de Greef M, Timmons B . The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev. 2009; 15:6-41. View

11.

Woods J, Ceddia M, Wolters B, Evans J, Lu Q, McAuley E . Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech Ageing Dev. 1999; 109(1):1-19. DOI: 10.1016/s0047-6374(99)00014-7. View

12.

Timmerman K, Flynn M, Coen P, Markofski M, Pence B . Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?. J Leukoc Biol. 2008; 84(5):1271-8. DOI: 10.1189/jlb.0408244. View

13.

Allin K, Nordestgaard B, Zacho J, Tybjaerg-Hansen A, Bojesen S . C-reactive protein and the risk of cancer: a mendelian randomization study. J Natl Cancer Inst. 2010; 102(3):202-6. DOI: 10.1093/jnci/djp459. View

14.

Santulli G, Iaccarino G . Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes. Immun Ageing. 2013; 10(1):10. PMC: 3763845. DOI: 10.1186/1742-4933-10-10. View

15.

Wang J, Song H, Tang X, Yang Y, Vieira V, Niu Y . Effect of exercise training intensity on murine T-regulatory cells and vaccination response. Scand J Med Sci Sports. 2011; 22(5):643-52. DOI: 10.1111/j.1600-0838.2010.01288.x. View

16.

Libardi C, de Souza G, Cavaglieri C, Madruga V, Chacon-Mikahil M . Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc. 2011; 44(1):50-6. DOI: 10.1249/MSS.0b013e318229d2e9. View

17.

Collier S, Kanaley J, Carhart Jr R, Frechette V, Tobin M, Hall A . Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre- and stage-1 hypertensives. J Hum Hypertens. 2008; 22(10):678-86. DOI: 10.1038/jhh.2008.36. View

18.

Zoppini G, Targher G, Zamboni C, Venturi C, Cacciatori V, Moghetti P . Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2006; 16(8):543-9. DOI: 10.1016/j.numecd.2005.09.004. View

19.

Bote M, Garcia J, Hinchado M, Ortega E . An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: role of IL-8 and noradrenaline. Brain Behav Immun. 2013; 39:107-12. DOI: 10.1016/j.bbi.2013.11.009. View

20.

Linke A, Schoene N, Gielen S, Hofer J, Erbs S, Schuler G . Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. J Am Coll Cardiol. 2001; 37(2):392-7. DOI: 10.1016/s0735-1097(00)01108-6. View