Candida Endocarditis: A Review of the Pathogenesis, Morphology, Risk Factors, and Management of an Emerging and Serious Condition

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2020 Feb 28

PMID 32104631

Citations 20

Authors

Sahil Mamtani

Nawar Muneer Aljanabi

Robins P Gupta Rauniyar

Ashu Acharya

Bilal Haider Malik

Affiliations

Soon will be listed here.

Abstract

Infective endocarditis is a significant healthcare burden due to the associated high mortality and complications. Endocarditis caused by both and non- (NCAC) species has been associated with a substantial rise in in-hospital morbidity and mortality. We used the Pubmed database to identify 47 out of 101 articles that had met our inclusion and exclusion criteria. We had put in place a broad inclusion criterion with no age or gender restrictions. These 47 articles included abstracts, 11 review articles, 13 case reports, 10 research articles, 1 clinical trial report, 1 meta-analysis, and other research articles. And they comprehensively cover the pathogenesis, risk factors, and management of infections caused by and NCAC species in the past 26 years. The articles we scanned provided us with information on different associations in correlation to multiple types of species. Here, we discuss the association between and endocarditis, a major cause of morbidity and mortality in both and NCAC. We also present our understanding regarding this interesting association and attempt to address some of the recurring questions.

Citing Articles

Embolic risk management in infective endocarditis: predicting the 'embolic roulette'.

Serban A, Pepine D, Inceu A, Dadarlat A, Achim A Open Heart. 2025; 12(1).

PMID: 39890159 PMC: 11792284. DOI: 10.1136/openhrt-2024-003060.

Multidisciplinary treatment for infective endocarditis complicated with systemic multiple abscess due to Panton-Valentine leukocidin producing community-acquired methicillin-resistant Staphylococcus aureus and Candida albicans: a case report.

Terata K, Saito S, Niitsuma K, Ohkusu M, Takeuchi N, Ishiwada N Gen Thorac Cardiovasc Surg Cases. 2024; 2(1):36.

PMID: 39517029 PMC: 11533610. DOI: 10.1186/s44215-023-00057-y.

Recurrent fungal endocarditis of the aortic valve: A challenging clinical scenario.

Bellamy S, Mirza M, Umar M, Enyia J, Malik K, Ameen A Clin Case Rep. 2024; 12(10):e9496.

PMID: 39450199 PMC: 11499069. DOI: 10.1002/ccr3.9496.

Game Changer or More of the Same? A Comparative Meta-analysis of Rezafungin and Caspofungin in Treating Candidemia and Invasive Candidiasis.

Sarfraz Z, Nasir Z, Javad F, Khan A, Shah B, Khalid M J Community Hosp Intern Med Perspect. 2024; 14(5):1-6.

PMID: 39399196 PMC: 11466332. DOI: 10.55729/2000-9666.1391.

Embolic Events in Infective Endocarditis: A Comprehensive Review.

Cabezon G, Pulido P, Lopez Diaz J, de Miguel-Alava M, Vilacosta I, Garcia-Azorin D Rev Cardiovasc Med. 2024; 25(3):97.

PMID: 39076945 PMC: 11263858. DOI: 10.31083/j.rcm2503097.

References

Toyoda S, Tajima E, Fukuda R, Masawa T, Inami S, Amano H . Early surgical intervention and optimal medical treatment for Candida parapsilosis endocarditis. Intern Med. 2015; 54(4):411-3. DOI: 10.2169/internalmedicine.54.2989. View

Ellis M, Al-Abdely H, Sandridge A, Greer W, Ventura W . Fungal endocarditis: evidence in the world literature, 1965-1995. Clin Infect Dis. 2000; 32(1):50-62. DOI: 10.1086/317550. View

Ramage G, Martinez J, Lopez-Ribot J . Candida biofilms on implanted biomaterials: a clinically significant problem. FEMS Yeast Res. 2006; 6(7):979-86. DOI: 10.1111/j.1567-1364.2006.00117.x. View

Fidel Jr P, Vazquez J, Sobel J . Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999; 12(1):80-96. PMC: 88907. DOI: 10.1128/CMR.12.1.80. View

Pfaller M, Moet G, Messer S, Jones R, Castanheira M . Geographic variations in species distribution and echinocandin and azole antifungal resistance rates among Candida bloodstream infection isolates: report from the SENTRY Antimicrobial Surveillance Program (2008 to 2009). J Clin Microbiol. 2010; 49(1):396-9. PMC: 3020436. DOI: 10.1128/JCM.01398-10. View

Brunke S, Hube B . Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cell Microbiol. 2012; 15(5):701-8. PMC: 3654559. DOI: 10.1111/cmi.12091. View

Baddley J, Benjamin Jr D, Patel M, Miro J, Athan E, Barsic B . Candida infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008; 27(7):519-29. PMC: 2757733. DOI: 10.1007/s10096-008-0466-x. View

Lefort A, Chartier L, Sendid B, Wolff M, Mainardi J, Podglajen I . Diagnosis, management and outcome of Candida endocarditis. Clin Microbiol Infect. 2012; 18(4):E99-E109. DOI: 10.1111/j.1469-0691.2012.03764.x. View

Steinbach W, Perfect J, Cabell C, Fowler V, Corey G, Li J . A meta-analysis of medical versus surgical therapy for Candida endocarditis. J Infect. 2005; 51(3):230-47. DOI: 10.1016/j.jinf.2004.10.016. View

10.

Bauer B, Schulze A, Loher A, Reinke F, Eckardt L . defibrillator endocarditis: A case report and review of current literature. Med Mycol Case Rep. 2019; 25:1-9. PMC: 6582067. DOI: 10.1016/j.mmcr.2019.06.001. View

11.

Silva S, Negri M, Henriques M, Oliveira R, Williams D, Azeredo J . Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2011; 36(2):288-305. DOI: 10.1111/j.1574-6976.2011.00278.x. View

12.

Thakkar Rivera N, Bray N, Wang H, Zelnick K, Osman A, Vicuna R . Rare infection of implantable cardioverter-defibrillator lead with Candida albicans: case report and literature review. Ther Adv Cardiovasc Dis. 2014; 8(5):193-201. DOI: 10.1177/1753944714539406. View

13.

Ammannaya G, Sripad N . Fungal endocarditis: what do we know in 2019?. Kardiol Pol. 2019; 77(7-8):670-673. DOI: 10.33963/KP.14869. View

14.

Barchiesi F, Orsetti E, Mazzanti S, Trave F, Salvi A, Nitti C . Candidemia in the elderly: What does it change?. PLoS One. 2017; 12(5):e0176576. PMC: 5426612. DOI: 10.1371/journal.pone.0176576. View

15.

Rodrigues C, Silva S, Henriques M . Candida glabrata: a review of its features and resistance. Eur J Clin Microbiol Infect Dis. 2013; 33(5):673-88. DOI: 10.1007/s10096-013-2009-3. View

16.

Poowanawittayakom N, Dutta A, Stock S, Touray S, Ellison 3rd R, Levitz S . Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA. Emerg Infect Dis. 2018; 24(4). PMC: 5875264. DOI: 10.3201/eid2404.171807. View

17.

Giuliano S, Guastalegname M, Russo A, Falcone M, Ravasio V, Rizzi M . Candida endocarditis: systematic literature review from 1997 to 2014 and analysis of 29 cases from the Italian Study of Endocarditis. Expert Rev Anti Infect Ther. 2017; 15(9):807-818. DOI: 10.1080/14787210.2017.1372749. View

18.

Talarmin J, Boutoille D, Tattevin P, Abgueguen P, Ansart S, Roblot F . Candida endocarditis: role of new antifungal agents. Mycoses. 2008; 52(1):60-6. DOI: 10.1111/j.1439-0507.2008.01533.x. View

19.

Trofa D, Gacser A, Nosanchuk J . Candida parapsilosis, an emerging fungal pathogen. Clin Microbiol Rev. 2008; 21(4):606-25. PMC: 2570155. DOI: 10.1128/CMR.00013-08. View

20.

Chowdhury W, Uzair Lodhi M, Syed I, Rahim U, Miller M, Rahim M . Catheter-Related Candida Endocarditis on the Right Atrial Septum - A Case Report. Cureus. 2018; 10(2):e2158. PMC: 5886732. DOI: 10.7759/cureus.2158. View