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Evaluation of Gum Mastic As a Microencapsulating and Matrix Forming Material for Sustained Drug Release

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Date 2020 Feb 28
PMID 32104355
Citations 6
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Abstract

In this study, a natural gum mastic was evaluated as a microencapsulating and matrix-forming material for sustained drug release. Mastic was characterized for its physicochemical properties. Microparticles were prepared by oil-in-oil solvent evaporation method. Matrix tablets were prepared by wet and melt granulation techniques. Diclofenac sodium (DFS) and diltiazem hydrochloride (DLTZ) were used as model drugs. Mastic produced discrete and spherical microspheres with DLTZ and microcapsules with DFS. Particle size and drug loading of microparticles was in the range of 22-62 µm and 50-87%, respectively. Increase in mastic: drug ratio increased microparticle size, improved drug loading and decreased the drug release rate. Microparticles with gum: drug ratio of 2:1 could sustain DLTZ release up to 12 h and released 57% DFS in 12 h. Mastic produced tablets with acceptable pharmacotechnical properties. A 30% w/w of mastic in tablet could sustain DLTZ release for 5 h from wet granulation, and DFS release for 8 h and 11 h from wet and melt granulation, respectively. Results revealed that a natural gum mastic can be used successfully to formulate matrix tablets and microparticles for sustained drug release.

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References
1.
Marone P, Bono L, Leone E, Bona S, Carretto E, Perversi L . Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori. J Chemother. 2002; 13(6):611-4. DOI: 10.1179/joc.2001.13.6.611. View

2.
McGee J, Singh M, Li X, Qiu H, OHagan D . The encapsulation of a model protein in poly (D, L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility. J Microencapsul. 1997; 14(2):197-210. DOI: 10.3109/02652049709015333. View

3.
Lin Y, Vasavada R . Studies on microencapsulation of 5-fluorouracil with poly(ortho ester) polymers. J Microencapsul. 2000; 17(1):1-11. DOI: 10.1080/026520400288517. View

4.
Nande V, Barabde U, Morkhade D, Joshi S, Patil A . Investigation of PEGylated derivatives of rosin as sustained release film formers. AAPS PharmSciTech. 2008; 9(1):105-11. PMC: 2976905. DOI: 10.1208/s12249-007-9025-5. View

5.
Narayani R, Rao K . Controlled release of anticancer drug methotrexate from biodegradable gelatin microspheres. J Microencapsul. 1994; 11(1):69-77. DOI: 10.3109/02652049409040439. View