Mixed PEGylated Surfactant Modifying System Decrease the Accelerated Blood Clearance Phenomenon of Nanoemulsions in Rats

Overview

Journal Asian J Pharm Sci

Date 2020 Feb 28

PMID 32104311

Citations 4

Authors

Yuqing Su

Wenya Tang

Yanzhi Song

Chunling Wang

Qingjing Tian

Xuling Wang

Jingjing Quan

Buoqun Li

Shaoning Wang

Yihui Deng

Affiliations

Soon will be listed here.

Abstract

The accelerated blood clearance (ABC) phenomenon which is induced by repeated injection of poly (ethylene glycol) (PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response. A novel 4-arm poly (ethylene glycol-5000)-cholesteryl methyl amide (4-arm PEG-CHMA) has been synthesized. The structure of 4-arm PEG-CHMA was confirmed by IR and H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate (TN)-loaded nanoemulsions modified with 4-arm PEG-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000] (mPEG-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG-CHMA and mPEG-DSPE (CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, respectively. The circulation time of the CPNEs were comparable to the mPEG-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose.

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