Changes in Expression of Serum Chemokine CXCL13 and IL-6 After Hip Replacement, and the Relationship with Lower Limb Vein Thrombus

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2020 Feb 28

PMID 32104273

Citations 1

Authors

Zhiyu Guan

Affiliations

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Abstract

Changes in the expression of serum chemokine CXC ligand 13 (CXCL13) and interleukin-6 (IL-6), and the relationship with lower limb vein thrombus were explored. A total of 128 patients undergoing hip replacement in The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from May 2017 to June 2019 were selected, and the patients suffering from lower limb vein thrombus were enrolled as group A and other patients not suffering from it were enrolled as group B. Enzyme-linked immuno-sorbent assay was employed to determine the levels of serum chemokine CXCL13 and IL-6, and receiver operating characteristic curves of serum chemokine CXCL13 and IL-6 levels in diagnosing restenosis after surgery were drawn. Pearson's correlation coefficient was adopted to analyze the correlation between serum chemokine CXCL13 and IL-6, and the logistic regression analysis to analyze the risk factors affecting hip replacement in patients. The levels of serum CXCL13 and IL-6 in group A were significantly higher than those in group B (both P<0.001). The specificity and sensitivity of serum CXCL13 level in diagnosis of lower limb vein thrombus after hip replacement were 61.76 and 80.00%, respectively, and those of serum IL-6 level in diagnosis were 70.59 and 66.67%, respectively. Serum CXCL13 level was positively correlated with serum IL-6 level (P<0.001), and age, body mass index (BMI), CXCL13 level and IL-6 level of the patients were independent risk factors affecting the efficacy of hip replacement. Serum CXCL13 level and serum IL-6 level can be used as biological indexes for prediction of early lower limb vein thrombus after hip replacement, and logistic regression analysis revealed that the age of the patients, BMI, diabetes history, hyperlipidemia history, hypertension history, CXCL13 level and IL-6 level are independent risk factors affecting the efficacy of hip replacement.

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References

Li Y, Xiao W, Luo W . Cellular aging towards osteoarthritis. Mech Ageing Dev. 2017; 162:80-84. DOI: 10.1016/j.mad.2016.12.012. View

Zagra L . Advances in hip arthroplasty surgery: what is justified?. EFORT Open Rev. 2017; 2(5):171-178. PMC: 5467678. DOI: 10.1302/2058-5241.2.170008. View

Rogers B, Garbedian S, Kuchinad R, Backstein D, Safir O, Gross A . Total hip arthroplasty for adult hip dysplasia. J Bone Joint Surg Am. 2012; 94(19):1809-21. DOI: 10.2106/JBJS.K.00779. View

Knight S, Aujla R, Biswas S . Total Hip Arthroplasty - over 100 years of operative history. Orthop Rev (Pavia). 2012; 3(2):e16. PMC: 3257425. DOI: 10.4081/or.2011.e16. View

Learmonth I, Young C, Rorabeck C . The operation of the century: total hip replacement. Lancet. 2007; 370(9597):1508-19. DOI: 10.1016/S0140-6736(07)60457-7. View

Shimoyama Y, Sawai T, Tatsumi S, Nakahira J, Oka M, Nakajima M . Perioperative risk factors for deep vein thrombosis after total hip arthroplasty or total knee arthroplasty. J Clin Anesth. 2012; 24(7):531-6. DOI: 10.1016/j.jclinane.2012.02.008. View

Rose-John S . The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation. Clin Pharmacol Ther. 2017; 102(4):591-598. DOI: 10.1002/cpt.782. View

Fisher W . Impact of venous thromboembolism on clinical management and therapy after hip and knee arthroplasty. Can J Surg. 2011; 54(5):344-51. PMC: 3195664. DOI: 10.1503/cjs.007310. View

Lankeit M, Held M . Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?. Eur Respir J. 2016; 47(2):369-73. DOI: 10.1183/13993003.01679-2015. View

10.

Nam D, Nunley R, Johnson S, Keeney J, Clohisy J, Barrack R . The Effectiveness of a Risk Stratification Protocol for Thromboembolism Prophylaxis After Hip and Knee Arthroplasty. J Arthroplasty. 2016; 31(6):1299-1306. DOI: 10.1016/j.arth.2015.12.007. View

11.

Gademan M, Hofstede S, Vliet Vlieland T, Nelissen R, Marang-van de Mheen P . Indication criteria for total hip or knee arthroplasty in osteoarthritis: a state-of-the-science overview. BMC Musculoskelet Disord. 2016; 17(1):463. PMC: 5103467. DOI: 10.1186/s12891-016-1325-z. View

12.

Sapan H, Paturusi I, Jusuf I, Patellongi I, Massi M, Pusponegoro A . Pattern of cytokine (IL-6 and IL-10) level as inflammation and anti-inflammation mediator of multiple organ dysfunction syndrome (MODS) in polytrauma. Int J Burns Trauma. 2016; 6(2):37-43. PMC: 4913232. View

13.

Jameson S, Bottle A, Malviya A, Muller S, Reed M . The impact of national guidelines for the prophylaxis of venous thromboembolism on the complications of arthroplasty of the lower limb. J Bone Joint Surg Br. 2010; 92(1):123-9. DOI: 10.1302/0301-620X.92B1.22751. View

14.

Han B, Kuzin I, Gaughan J, Olsen N, Bottaro A . Baseline CXCL10 and CXCL13 levels are predictive biomarkers for tumor necrosis factor inhibitor therapy in patients with moderate to severe rheumatoid arthritis: a pilot, prospective study. Arthritis Res Ther. 2016; 18:93. PMC: 4840903. DOI: 10.1186/s13075-016-0995-0. View

15.

Fukushima K, Takahira N, Uchiyama K, Moriya M, Minato T, Takaso M . The incidence of deep vein thrombosis (DVT) during hip arthroscopic surgery. Arch Orthop Trauma Surg. 2016; 136(10):1431-5. DOI: 10.1007/s00402-016-2508-7. View

16.

Wang M, Yang L, Yang X, Zhang R, Hou L, Liu X . [Correlation of inflammatory marker and coagulation factors with deep vein thrombosis]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010; 18(3):753-6. View

17.

Liu X, Zi Y, Xiang L, Wang Y . Total hip arthroplasty: areview of advances, advantages and limitations. Int J Clin Exp Med. 2015; 8(1):27-36. PMC: 4358426. View

18.

Iba T, Levy J . Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. J Thromb Haemost. 2017; 16(2):231-241. DOI: 10.1111/jth.13911. View

19.

Rahmati M, Nalesso G, Mobasheri A, Mozafari M . Aging and osteoarthritis: Central role of the extracellular matrix. Ageing Res Rev. 2017; 40:20-30. DOI: 10.1016/j.arr.2017.07.004. View

20.

Wang J, Yang L, Li Q, Wu Z, Sun Y, Zou Q . Construction of an adherence rating scale for exercise therapy for patients with knee osteoarthritis. BMC Musculoskelet Disord. 2018; 19(1):263. PMC: 6064120. DOI: 10.1186/s12891-018-2200-x. View