Experience Shapes Activity Dynamics and Stimulus Coding of VIP Inhibitory Cells

Overview

Journal Elife

Specialty Biology

Date 2020 Feb 27

PMID 32101169

Citations 40

Authors

Marina Garrett

Sahar Manavi

Kate Roll

Douglas R Ollerenshaw

Peter A Groblewski

Nicholas D Ponvert

Justin T Kiggins

Linzy Casal

Kyla Mace

Ali Williford

Arielle Leon

Xiaoxuan Jia

Peter Ledochowitsch

Michael A Buice

Wayne Wakeman

Stefan Mihalas

Shawn R Olsen

Affiliations

Soon will be listed here.

Abstract

Cortical circuits can flexibly change with experience and learning, but the effects on specific cell types, including distinct inhibitory types, are not well understood. Here we investigated how excitatory and VIP inhibitory cells in layer 2/3 of mouse visual cortex were impacted by visual experience in the context of a behavioral task. Mice learned a visual change detection task with a set of eight natural scene images. Subsequently, during 2-photon imaging experiments, mice performed the task with these familiar images and three sets of novel images. Strikingly, the temporal dynamics of VIP activity differed markedly between novel and familiar images: VIP cells were stimulus-driven by novel images but were suppressed by familiar stimuli and showed ramping activity when expected stimuli were omitted from a temporally predictable sequence. This prominent change in VIP activity suggests that these cells may adopt different modes of processing under novel versus familiar conditions.

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