Long-term Health of Children Conceived After Assisted Reproductive Technology

Overview

Journal Ups J Med Sci

Specialty General Medicine

Date 2020 Feb 27

PMID 32101068

Citations 18

Authors

Christina Bergh

Ulla-Britt Wennerholm

Affiliations

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Abstract

The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a similar outcome for many health conditions as their spontaneously conceived peers. For some outcomes, particularly cardiovascular function and diabetes, studies show some higher risk for ART singletons or subgroup of ART singletons. The fast introduction of new ART techniques emphasizes the importance of continuous surveillance of children born after ART.

Citing Articles

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References

Sandin S, Nygren K, Iliadou A, Hultman C, Reichenberg A . Autism and mental retardation among offspring born after in vitro fertilization. JAMA. 2013; 310(1):75-84. DOI: 10.1001/jama.2013.7222. View

Kallen B, Finnstrom O, Nygren K, Olausson P . Asthma in Swedish children conceived by in vitro fertilisation. Arch Dis Child. 2012; 98(2):92-6. DOI: 10.1136/archdischild-2012-301822. View

Norrman E, Petzold M, Clausen T, Henningsen A, Opdahl S, Pinborg A . Type 1 diabetes in children born after assisted reproductive technology: a register-based national cohort study. Hum Reprod. 2020; 35(1):221-231. DOI: 10.1093/humrep/dez227. View

Belva F, Roelants M, De Schepper J, Van Steirteghem A, Tournaye H, Bonduelle M . Reproductive hormones of ICSI-conceived young adult men: the first results. Hum Reprod. 2016; 32(2):439-446. DOI: 10.1093/humrep/dew324. View

Goldsmith S, McIntyre S, Badawi N, Hansen M . Cerebral palsy after assisted reproductive technology: a cohort study. Dev Med Child Neurol. 2017; 60(1):73-80. DOI: 10.1111/dmcn.13577. View

Middelburg K, Heineman M, Bos A, Hadders-Algra M . Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI-a systematic review. Hum Reprod Update. 2008; 14(3):219-31. DOI: 10.1093/humupd/dmn005. View

Carson C, Sacker A, Kelly Y, Redshaw M, Kurinczuk J, Quigley M . Asthma in children born after infertility treatment: findings from the UK Millennium Cohort Study. Hum Reprod. 2012; 28(2):471-9. PMC: 3545639. DOI: 10.1093/humrep/des398. View

Sundh K, Henningsen A, Kallen K, Bergh C, Romundstad L, Gissler M . Cancer in children and young adults born after assisted reproductive technology: a Nordic cohort study from the Committee of Nordic ART and Safety (CoNARTaS). Hum Reprod. 2014; 29(9):2050-7. DOI: 10.1093/humrep/deu143. View

Spaan M, van den Belt-Dusebout A, van den Heuvel-Eibrink M, Hauptmann M, Lambalk C, Burger C . Risk of cancer in children and young adults conceived by assisted reproductive technology. Hum Reprod. 2019; 34(4):740-750. PMC: 6443110. DOI: 10.1093/humrep/dey394. View

10.

Spector L, Brown M, Wantman E, Letterie G, Toner J, Doody K . Association of In Vitro Fertilization With Childhood Cancer in the United States. JAMA Pediatr. 2019; 173(6):e190392. PMC: 6547076. DOI: 10.1001/jamapediatrics.2019.0392. View

11.

Liu L, Gao J, He X, Cai Y, Wang L, Fan X . Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis. Sci Rep. 2017; 7:46207. PMC: 5384197. DOI: 10.1038/srep46207. View

12.

Knoester M, Helmerhorst F, Vandenbroucke J, van der Westerlaken L, Walther F, Veen S . Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception. Fertil Steril. 2007; 90(2):289-96. DOI: 10.1016/j.fertnstert.2007.06.090. View

13.

Kissin D, Zhang Y, Boulet S, Fountain C, Bearman P, Schieve L . Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children. Hum Reprod. 2014; 30(2):454-65. PMC: 4287306. DOI: 10.1093/humrep/deu338. View

14.

Bay B, Mortensen E, Kesmodel U . Assisted reproduction and child neurodevelopmental outcomes: a systematic review. Fertil Steril. 2013; 100(3):844-53. DOI: 10.1016/j.fertnstert.2013.05.034. View

15.

Spangmose A, Malchau S, Schmidt L, Vassard D, Rasmussen S, Loft A . Academic performance in adolescents born after ART-a nationwide registry-based cohort study. Hum Reprod. 2017; 32(2):447-456. DOI: 10.1093/humrep/dew334. View

16.

Spangmose A, Malchau S, Henningsen A, Forman J, Rasmussen S, Loft A . Academic performance in adolescents aged 15-16 years born after frozen embryo transfer compared with fresh embryo transfer: a nationwide registry-based cohort study. BJOG. 2018; 126(2):261-269. DOI: 10.1111/1471-0528.15484. View

17.

Kallen A, Finnstrom O, Lindam A, Nilsson E, Nygren K, Otterblad Olausson P . Cerebral palsy in children born after in vitro fertilization. Is the risk decreasing?. Eur J Paediatr Neurol. 2010; 14(6):526-30. DOI: 10.1016/j.ejpn.2010.03.007. View

18.

Williams C, Bunch K, Stiller C, Murphy M, Botting B, Wallace W . Cancer risk among children born after assisted conception. N Engl J Med. 2013; 369(19):1819-27. DOI: 10.1056/NEJMoa1301675. View

19.

Hargreave M, Jensen A, Hansen M, Dehlendorff C, Winther J, Schmiegelow K . Association Between Fertility Treatment and Cancer Risk in Children. JAMA. 2019; 322(22):2203-2210. PMC: 7081748. DOI: 10.1001/jama.2019.18037. View

20.

Stromberg B, Dahlquist G, Ericson A, Finnstrom O, Koster M, Stjernqvist K . Neurological sequelae in children born after in-vitro fertilisation: a population-based study. Lancet. 2002; 359(9305):461-5. DOI: 10.1016/S0140-6736(02)07674-2. View