Influence of Non-steroidal Anti-inflammatory Drugs on the Inflammatory Sonographic Features in Erosive Hand Osteoarthritis: an Intervention Study

Overview

Journal Rheumatol Adv Pract

Publisher Oxford University Press

Specialty Rheumatology

Date 2020 Feb 27

PMID 32099954

Citations 1

Authors

Qun Xia Xu

Ruth Wittoek

Affiliations

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Abstract

Objective: The aim was to examine whether inflammatory US features in erosive hand OA patients change when discontinuing intake of NSAIDs before US examination in a non-randomized study.

Methods: Patients ( = 99) were allocated to the NSAIDs or control group according to their intake at baseline. US was performed at baseline (T0) and 2 weeks after discontinuation of NSAIDs (T1). Inflammatory features (i.e. synovial proliferation, effusion and power Doppler signal) were scored using a semi-quantitative scale (from zero to three). Pain levels were scored on a numerical rating scale. Binomial mixed models were fitted for US features, and odds ratios of having a US score of at least two at most one for synovial proliferation and effusion, and zero at least one for power Doppler were calculated.

Results: At baseline, both groups [NSAIDs group ( = 47) control group ( = 52)] were comparable for numerical rating scale pain, disease duration, number of radiographically affected joints, BMI and US baseline data, but not for age ( = 0.005). At T1, more synovial proliferation and power Doppler signal was seen compared with T0 in the NSAIDs group ( = 0.018 and 0.031, respectively). However, the interaction term time*NSAIDs was not found to be significant for any variable. The numerical rating scale pain at T1 was higher compared with baseline, although statistically non-significant.

Conclusion: No significant changes in inflammatory US features were seen in patients with erosive hand OA after withdrawal of NSAIDs for 2 weeks. This study suggests that an NSAID-free period is not necessary before assessing inflammatory disease activity in erosive hand OA.

Citing Articles

Inflammation as a therapeutic target for osteoarthritis: A literature review of clinical trials.

Zhu R, Fang H, Wang J, Ge L, Zhang X, Aitken D Clin Rheumatol. 2024; 43(8):2417-2433.

PMID: 38961031 PMC: 11269414. DOI: 10.1007/s10067-024-07042-y.

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