Forced Oscillation Technique As a Predictor for Loss of Control in Asthmatic Children

Overview

Journal Asia Pac Allergy

Publisher Wolters Kluwer

Date 2020 Feb 27

PMID 32099825

Citations 4

Authors

Piyawut Kreetapirom

Potjanee Kiewngam

Wanlapa Jotikasthira

Wasu Kamchaisatian

Suwat Benjaponpitak

Wiparat Manuyakorn

Affiliations

Soon will be listed here.

Abstract

Background: A reliable objective tool using as a predictor of asthma control status could assist asthma management.

Objective: To find the parameters of forced oscillation technique (FOT) as predictors for the future loss of asthma symptom control.

Methods: Children with well-controlled asthma symptom, aged 6-12 years, were recruited for a 12-week prospective study. FOT and spirometer measures and their bronchodilator response were evaluated at baseline. The level of asthma symptom control was evaluated according to Global Initiative for Asthma.

Results: Among 68 recruited children, 41 children (60.3%) maintain their asthma control between 2 visits (group C-C), and 27 children (39.7%) lost their asthma control on the follow-up visit (group C-LC). Baseline FOT parameters, including the values of respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), respiratory reactance at 5 Hz, area of reactance, %predicted of R5 and percentage of bronchodilator response (%∆) of R5 and R20 were significantly different between C-C and C-LC groups. In contrast, only %∆ of forced vital capacity, forced expiratory volume in 1 second (FEV), and FEF (forced expiratory flow 25%-75%) were significantly different between groups. Multiple logistic regression analysis revealed that %predicted of R5, %∆R5, %predicted of FEV and %∆FEV were the predictive factors for predicting the future loss of asthma control. The following cutoff values demonstrated the best sensitivity and specificity for predicting loss of asthma control: %predicted of R5=91.28, %∆R5=21.2, %predicted of FEV=89.5, and %∆FEV=7.8. The combination of these parameters predicted the risk of loss of asthma control with area under the curve of 0.924, accuracy of 83.8%.

Conclusion: Resistance FOT measures have an additive role to spirometric parameter in predicting future loss of asthma control.

Citing Articles

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References

Heffler E, Crimi C, Campisi R, Sichili S, Nicolosi G, Porto M . Bronchodilator response as a marker of poor asthma control. Respir Med. 2016; 112:45-50. DOI: 10.1016/j.rmed.2016.01.012. View

Cabral A, Vollmer W, Barbirotto R, Martins M . Exhaled nitric oxide as a predictor of exacerbation in children with moderate-to-severe asthma: a prospective, 5-month study. Ann Allergy Asthma Immunol. 2009; 103(3):206-11. DOI: 10.1016/S1081-1206(10)60183-4. View

Song T, Kim K, Kim E, Park J, Sohn M, Kim K . Utility of impulse oscillometry in young children with asthma. Pediatr Allergy Immunol. 2008; 19(8):763-8. DOI: 10.1111/j.1399-3038.2008.00734.x. View

Schulze J, Smith H, Fuchs J, Herrmann E, Dressler M, Rose M . Methacholine challenge in young children as evaluated by spirometry and impulse oscillometry. Respir Med. 2012; 106(5):627-34. DOI: 10.1016/j.rmed.2012.01.007. View

Brashier B, Salvi S . Measuring lung function using sound waves: role of the forced oscillation technique and impulse oscillometry system. Breathe (Sheff). 2015; 11(1):57-65. PMC: 4487383. DOI: 10.1183/20734735.020514. View

Carroll W, Wildhaber J, Brand P . Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey. Eur Respir J. 2011; 39(1):90-6. DOI: 10.1183/09031936.00048911. View

Schulze J, Biedebach S, Christmann M, Herrmann E, Voss S, Zielen S . Impulse Oscillometry as a Predictor of Asthma Exacerbations in Young Children. Respiration. 2016; 91(2):107-14. DOI: 10.1159/000442448. View

Bisgaard H, Klug B . Lung function measurement in awake young children. Eur Respir J. 1995; 8(12):2067-75. DOI: 10.1183/09031936.95.08122067. View

Skylogianni E, Douros K, Anthracopoulos M, Fouzas S . The Forced Oscillation Technique in Paediatric Respiratory Practice. Paediatr Respir Rev. 2016; 18:46-51. DOI: 10.1016/j.prrv.2015.11.001. View

10.

Fuhlbrigge A, Kitch B, Paltiel A, Kuntz K, Neumann P, Dockery D . FEV(1) is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol. 2001; 107(1):61-7. DOI: 10.1067/mai.2001.111590. View

11.

Oostveen E, MacLeod D, Lorino H, Farre R, Hantos Z, Desager K . The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003; 22(6):1026-41. DOI: 10.1183/09031936.03.00089403. View

12.

Farah C, King G, Brown N, Downie S, Kermode J, Hardaker K . The role of the small airways in the clinical expression of asthma in adults. J Allergy Clin Immunol. 2011; 129(2):381-7, 387.e1. DOI: 10.1016/j.jaci.2011.11.017. View

13.

Manoharan A, Anderson W, Lipworth J, Lipworth B . Assessment of spirometry and impulse oscillometry in relation to asthma control. Lung. 2014; 193(1):47-51. DOI: 10.1007/s00408-014-9674-6. View

14.

Heijkenskjold Rentzhog C, Janson C, Berglund L, Borres M, Nordvall L, Alving K . Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control. Clin Exp Allergy. 2017; 47(12):1546-1554. DOI: 10.1111/cea.13035. View

15.

Zeiger R, Yegin A, Simons F, Haselkorn T, Rasouliyan L, Szefler S . Evaluation of the National Heart, Lung, and Blood Institute guidelines impairment domain for classifying asthma control and predicting asthma exacerbations. Ann Allergy Asthma Immunol. 2012; 108(2):81-7. DOI: 10.1016/j.anai.2011.12.001. View

16.

Bateman E, Reddel H, Eriksson G, Peterson S, Ostlund O, Sears M . Overall asthma control: the relationship between current control and future risk. J Allergy Clin Immunol. 2010; 125(3):600-8, 608.e1-608.e6. DOI: 10.1016/j.jaci.2009.11.033. View

17.

Pongracic J, Krouse R, Babineau D, Zoratti E, Cohen R, Wood R . Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents. J Allergy Clin Immunol. 2016; 138(4):1030-1041. PMC: 5379996. DOI: 10.1016/j.jaci.2016.06.059. View

18.

Marotta A, Klinnert M, Price M, Larsen G, Liu A . Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk for persistent asthma. J Allergy Clin Immunol. 2003; 112(2):317-22. DOI: 10.1067/mai.2003.1627. View

19.

Puranitee P, Kamchaisatian W, Manuyakorn W, Vilaiyuk S, Laecha O, Pattanaprateep O . Direct medical cost of Thai pediatric asthma management: a pilot study. Asian Pac J Allergy Immunol. 2015; 33(4):296-300. DOI: 10.12932/AP0494.33.4.2015. View

20.

Ferrer Galvan M, Alvarez Gutierrez F, Romero Falcon A, Romero Romero B, Saez A, Medina Gallardo J . Is the bronchodilator test an useful tool to measure asthma control?. Respir Med. 2017; 126:26-31. DOI: 10.1016/j.rmed.2017.03.008. View